دورية أكاديمية
Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high-fat diet-induced mice to alleviate obesity.
| العنوان: | Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high-fat diet-induced mice to alleviate obesity. |
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| المؤلفون: | Tian B; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China., Pan Y; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China., Zhou X; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China., Jiang Y; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China., Zhang X; Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, China., Luo X; Sichuan Three MT. TEA-INDUSTRY Co., Ltd, Guangyuan, China., Yang K; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China. |
| المصدر: | Journal of the science of food and agriculture [J Sci Food Agric] 2024 Aug 15; Vol. 104 (10), pp. 5882-5895. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons Original Publication: London, Society of Chemical Industry. |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*/drug effects , Diet, High-Fat*/adverse effects , Obesity*/metabolism , Obesity*/microbiology , Obesity*/drug therapy , Obesity*/diet therapy , Mice, Inbred C57BL* , Camellia sinensis*/chemistry , Signal Transduction*/drug effects , Plant Leaves*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , AMP-Activated Protein Kinases*/metabolism , Sterol Regulatory Element Binding Protein 1*/metabolism , Sterol Regulatory Element Binding Protein 1*/genetics, Animals ; Mice ; Male ; Humans ; Acetyl-CoA Carboxylase/metabolism ; Acetyl-CoA Carboxylase/genetics ; Tea/chemistry ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/drug effects ; Bacteria/metabolism ; Liver/metabolism ; Liver/drug effects ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/administration & dosage |
| مستخلص: | Background: Yellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O. Ktze, which has yellow leaves and the unique qualities of 'three green through three yellow'. The present study aimed to investigate the anti-obesity effect of YLGT in mice fed a high-fat diet (HFD) and to explore the potential mechanisms by regulating the AMPK/ACC/SREBP1c signaling pathways and gut microbiota. Results: The results showed that YLGT aqueous extract reduced body weight, hepatic inflammation, fat accumulation and hyperlipidemia in HFD-induced C57BL/6J mice, and also accelerated energy metabolism, reduced fat synthesis and suppressed obesity by activating the AMPK/CPT-1α signaling pathway and inhibiting the FAS/ACC/SREBP-1c signaling pathway. Fecal microbiota transplantation experiment further confirmed that the alteration of gut microbiota (e.g. increasing unclassified_Muribaculaceae and decreasing Colidextribacter) might be an important cause of YLGT water extract inhibiting obesity. Conclusion: In conclusion, YLGT has a broad application prospect in the treatment of obesity and the development of anti-obesity function beverages. © 2024 Society of Chemical Industry. (© 2024 Society of Chemical Industry.) |
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| معلومات مُعتمدة: | 2022C04036 Zhejiang Provincial Key Research and Development Program; 2023C02040 Zhejiang Provincial Key Research and Development Program |
| فهرسة مساهمة: | Keywords: energy metabolism; fecal microbiota transplantation; high‐fat diets; obesity; yellow leaf green tea |
| المشرفين على المادة: | 0 (Plant Extracts) EC 2.7.11.31 (AMP-Activated Protein Kinases) 0 (Sterol Regulatory Element Binding Protein 1) EC 6.4.1.2 (Acetyl-CoA Carboxylase) 0 (Tea) 0 (Anti-Obesity Agents) |
| تواريخ الأحداث: | Date Created: 20240226 Date Completed: 20240618 Latest Revision: 20240618 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1002/jsfa.13413 |
| PMID: | 38407390 |
| قاعدة البيانات: | MEDLINE |
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