دورية أكاديمية
أعرض في EDS

Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study.

التفاصيل البيبلوغرافية
العنوان: Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study.
المؤلفون: Enomoto N; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Health Administration Center, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: norieno@hama-med.ac.jp., Yazawa S; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Mochizuka Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Fukada A; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Tanaka Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Naoi H; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Aono Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan., Inoue Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Yasui H; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Karayama M; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Suzuki Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Hozumi H; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Furuhashi K; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Toyoshima M; Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Hamamatsu, Japan., Kono M; Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan., Imokawa S; Department of Respiratory Medicine, Iwata City Hospital, Iwata, Japan., Sano T; Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan., Akamatsu T; Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan., Koshimizu N; Department of Respiratory Medicine, Fujieda Municipal General Hospital, Fujieda, Japan., Yokomura K; Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan., Matsuda H; Department of Respiratory Medicine, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan., Kaida Y; Department of Respiratory Medicine, Enshu Hospital, Hamamatsu, Japan., Shirai M; Respiratory and Allergy Medicine, National Hospital Organization Tenryu Hospital, Hamamatsu, Japan., Mori K; Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan., Masuda M; Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan., Fujisawa T; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan., Inui N; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan., Nakamura Y; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan; Respiratory and Allergy Medicine, National Hospital Organization Tenryu Hospital, Hamamatsu, Japan., Sugiura H; Department of Radiology, National Defense Medical College, Saitama, Japan., Sumikawa H; Department of Radiology, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Kitani M; Department of Pathology, National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Tabata K; Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan., Ogawa N; Division of Immunology and Rheumatology, Department of Internal Medicine 3, Hamamatsu University School of Medicine, Hamamatsu, Japan., Suda T; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
المصدر: Respiratory medicine [Respir Med] 2024 Apr; Vol. 224, pp. 107577. Date of Electronic Publication: 2024 Feb 24.
نوع المنشور: Multicenter Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : Oxford : Elsevier
Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989-
مواضيع طبية MeSH: Autoimmune Diseases*/complications , Autoimmune Diseases*/diagnostic imaging , Lung Diseases, Interstitial*/diagnosis , Idiopathic Interstitial Pneumonias*/diagnosis , Connective Tissue Diseases*/complications , Connective Tissue Diseases*/diagnostic imaging, Humans ; Cohort Studies ; Prospective Studies ; Retrospective Studies
مستخلص: Background: Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship between findings on HRCT or lung histopathological specimens and the progression of interstitial pneumonia in patients with IPAF.
Methods: This multicentre cohort study prospectively enrolled consecutive patients with IIP. At the diagnosis of IIP, we systematically evaluated 74 features suggestive of connective tissue diseases and followed them up. HRCT, lung specimens, serum antibodies, and the clinical course were also evaluated.
Results: Among 222 patients with IIP, 26 (11.7%) fulfilled the IPAF criteria. During a median observation period of 36 months, patients with IPAF showed better survival than those without IPAF (p = 0.034). While histopathological findings were not related to IPAF, nonspecific interstitial pneumonia (NSIP) with organizing pneumonia (OP) overlap was the most prevalent HRCT pattern (p < 0.001) and the consolidation opacity was the most common radiological finding in IPAF (p = 0.017). Furthermore, in patients with IPAF, the diagnosis of COP or NSIP with OP overlap was associated with a higher increase in %FVC in 1 year than in those with idiopathic pulmonary fibrosis, NSIP, or unclassifiable IIP (p = 0.002).
Conclusions: This study shows the presence of consolidation opacity on HRCT and the diagnosis of COP or NSIP with OP overlap are associated with IPAF and its favourable treatment response in patients with IPAF.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Noriyuki Enomoto received funding from Boehringer Ingelheim Japan Co., Ltd. All of other authors did not receive funding.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Anti-aminoacyl tRNA synthetase (ARS) antibody; Idiopathic interstitial pneumonia; Interstitial pneumonia with autoimmune features; Nonspecific interstitial pneumonia; Organizing pneumonia
تواريخ الأحداث: Date Created: 20240226 Date Completed: 20240318 Latest Revision: 20240318
رمز التحديث: 20240318
DOI: 10.1016/j.rmed.2024.107577
PMID: 38408707
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-3064
DOI:10.1016/j.rmed.2024.107577