دورية أكاديمية
أعرض في EDS

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus.

التفاصيل البيبلوغرافية
العنوان: Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus.
المؤلفون: Garrison AR; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. aura.r.garrison.civ@health.mil., Moresco V; Division of Biomedical Sciences, University of California Riverside, Riverside, CA, USA., Zeng X; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Cline CR; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Ward MD; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Ricks KM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Olschner SP; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Cazares LH; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Karaaslan E; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA., Fitzpatrick CJ; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA., Bergeron É; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA., Pegan SD; Division of Biomedical Sciences, University of California Riverside, Riverside, CA, USA.; Department of Chemistry & Life Science, United States Military Academy, West Point, NY, USA., Golden JW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. joseph.w.golden.civ@health.mil.
المصدر: Nature communications [Nat Commun] 2024 Feb 26; Vol. 15 (1), pp. 1722. Date of Electronic Publication: 2024 Feb 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Hemorrhagic Fever Virus, Crimean-Congo*/metabolism , Hemorrhagic Fever, Crimean*/prevention & control, Female ; Animals ; Mice ; Nucleocapsid Proteins/metabolism ; Antibodies, Monoclonal ; Glycoproteins/metabolism ; Antibodies, Viral
مستخلص: Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV. Most efforts have focused on targeting the viral glycoproteins. However, glycoproteins are poorly conserved among viral strains. The CCHFV nucleocapsid protein (NP) is highly conserved between CCHFV strains. Here, we investigate the protective efficacy of a CCHFV monoclonal antibody targeting the NP. We find that an anti-NP monoclonal antibody (mAb-9D5) protected female mice against lethal CCHFV infection or resulted in a significant delay in mean time-to-death in mice that succumbed to disease compared to isotype control animals. Antibody protection is independent of Fc-receptor functionality and complement activity. The antibody bound NP from several CCHFV strains and exhibited robust cross-protection against the heterologous CCHFV strain Afg09-2990. Our work demonstrates that the NP is a viable target for antibody-based therapeutics, providing another direction for developing immunotherapeutics against CCHFV.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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معلومات مُعتمدة: R01 AI151006 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Nucleocapsid Proteins)
0 (Antibodies, Monoclonal)
0 (Glycoproteins)
0 (Antibodies, Viral)
تواريخ الأحداث: Date Created: 20240226 Date Completed: 20240228 Latest Revision: 20240516
رمز التحديث: 20240516
مُعرف محوري في PubMed: PMC10897337
DOI: 10.1038/s41467-024-46110-4
PMID: 38409240
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-46110-4