دورية أكاديمية
Diverse learners: learning disabilities and quality of life following mind-body and health education interventions for adults with neurofibromatosis.
| العنوان: | Diverse learners: learning disabilities and quality of life following mind-body and health education interventions for adults with neurofibromatosis. |
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| المؤلفون: | Kanaya MR; Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Suite 100, Boston, MA, 02114, USA., Greenberg J; Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Suite 100, Boston, MA, 02114, USA.; Harvard Medical School, Boston, MA, USA., Bakhshaie J; Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Suite 100, Boston, MA, 02114, USA.; Harvard Medical School, Boston, MA, USA., Vranceanu AM; Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Suite 100, Boston, MA, 02114, USA. avranceanu@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. avranceanu@mgh.harvard.edu. |
| المصدر: | Journal of neuro-oncology [J Neurooncol] 2024 Apr; Vol. 167 (2), pp. 315-322. Date of Electronic Publication: 2024 Feb 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York : Springer Original Publication: Boston : M. Nijhoff, 1983- |
| مواضيع طبية MeSH: | Neurofibromatoses*/psychology , Learning Disabilities*/etiology , Learning Disabilities*/therapy, Adult ; Humans ; Quality of Life ; Relaxation Therapy ; Health Education |
| مستخلص: | Purpose: Neurofibromatosis (NF) is associated with low quality-of-life (QoL). Learning disabilities are prevalent among those with NF, further worsening QoL and potentially impacting benefits from mind-body and educational interventions, yet research on this population is scarce. Here, we address this gap by comparing NF patients with and without learning disabilities on QoL at baseline and QoL-related gains following two interventions. Methods: Secondary analysis of a fully-powered RCT of a mind-body program (Relaxation Response Resiliency Program for NF; 3RP-NF) versus an educational program (Health Enhancement Program for NF; HEP-NF) among 228 adults with NF. Participants reported QoL in four domains (Physical Health, Psychological, Social Relationships, and Environmental). We compare data at baseline, post-treatment, and 12-month follow-up, controlling for intervention type. Results: At baseline, individuals with NF and learning disabilities had lower Psychological (T = -3.0, p = .001) and Environmental (T = -3.8, p < .001) QoL compared to those without learning disabilities. Both programs significantly improved all QoL domains (ps < .0001-0.002) from baseline to post-treatment, regardless of learning disability status. However, those with learning disabilities exceeded the minimal clinically important difference in only one domain (Psychological QoL) compared to three domains in individuals without learning disabilities. Moreover, those with learning disabilities failed to sustain statistically significant gains in Psychological QoL at 12-months, while those without learning disabilities sustained all gains. Conclusion: Adults with NF and learning disabilities have lower Psychological and Environmental QoL. While interventions show promise in improving QoL regardless of learning disabilities, additional measures may bolster clinical benefit and sustainability among those with learning disabilities. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | K23 AT010653 United States AT NCCIH NIH HHS; K24 AT011760 United States AT NCCIH NIH HHS; 5K24AT011760 United States AT NCCIH NIH HHS; K23AT01065301A1 United States AT NCCIH NIH HHS |
| فهرسة مساهمة: | Keywords: Learning disabilities; Neurofibromatosis; Quality of life |
| تواريخ الأحداث: | Date Created: 20240227 Date Completed: 20240418 Latest Revision: 20240902 |
| رمز التحديث: | 20240902 |
| مُعرف محوري في PubMed: | PMC11221342 |
| DOI: | 10.1007/s11060-024-04610-9 |
| PMID: | 38409461 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-7373 |
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| DOI: | 10.1007/s11060-024-04610-9 |