دورية أكاديمية
أعرض في EDS

The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study.

التفاصيل البيبلوغرافية
العنوان: The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study.
المؤلفون: Tan Y; Department of Endocrinology and Respiratory of the Third People's Hospital of Nanning, Nanning, Guangxi, 530003, People's Republic of China., Li Y; Medical Department of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China., Huang X; Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China., Zhai Z; Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China., Wang Q; Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China., Guo Y; Yuncheng Vocational and Technical University, Yuncheng, Shanxi, 044000, People's Republic of China., Li J; Hospital Dean's Office of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China., Lu W; Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China.
المصدر: Journal of inflammation research [J Inflamm Res] 2024 Feb 22; Vol. 17, pp. 1227-1240. Date of Electronic Publication: 2024 Feb 22 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101512684 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7031 (Print) Linking ISSN: 11787031 NLM ISO Abbreviation: J Inflamm Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, N.Z.] : Dove Medical Press
مستخلص: Objective: To explore the relationship between red blood cell distribution width to albumin (RDW/ALB) ratio (RAR) and the risk of rehospitalization and rehospitalization all-cause mortality in middle-aged and elderly survivors with sepsis based on an ambispective longitudinal cohort from the Intensive Care Unit (ICU).
Methods: Between 2017 and 2022, 455 adults who survived the first-episode severe sepsis without recurrence for at least 3 months were included in this study. All participants were followed up every 4 weeks for 12 months. According to the tertiles of RAR, participants were divided into three groups: low-level (≤0.36, n = 152), moderate-level (0.37-0.44, n = 152), and high-level (≥0.45, n = 151). The relationship between RAR and the risk of rehospitalization and rehospitalization all-cause mortality was evaluated.
Results: Out of 455 participants, 156 experienced rehospitalization (34.3%), of which 44 (28.2%) died. Receiver operating characteristic (ROC) analysis showed that the RAR cut-off values for rehospitalization and rehospitalization all-cause mortality were 0.4251 and 0.4743, respectively. Multivariate Cox regression analysis indicated that the RAR was positively associated with rehospitalization ( P = 0.011) and all-cause mortality ( P = 0.006). Compared with the low-level, the high-level RAR presented a higher dose-dependent rehospitalization risk ( P = 0.02) and rehospitalization all-cause mortality ( P = 0.044). The stratified analysis displayed that compared to the low-level, with the RAR increasing by 1.0, the risk for rehospitalization increased 3.602-fold in aged <65 patients ( P = 0.002) and 1.721-fold in female patients ( P = 0.014). Kaplan-Meier survival analysis implied a significant positive association between the RAR and the cumulative incidence of rehospitalization and rehospitalization all-cause mortality (log-rank, all P < 0.001).
Conclusion: RAR has a reliable predictive value for the risk of rehospitalization and rehospitalization all-cause mortality in patients with sepsis. Consequently, monitoring RAR for at least 1 year after surviving sepsis in female patients aged <65 in clinical practice is critical.
Competing Interests: The authors report no conflicts of interest in this study.
(© 2024 Tan et al.)
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فهرسة مساهمة: Keywords: albumin; red blood cell distribution width; rehospitalization; rehospitalization all-cause mortality; sepsis
تواريخ الأحداث: Date Created: 20240227 Latest Revision: 20240229
رمز التحديث: 20240229
مُعرف محوري في PubMed: PMC10896106
DOI: 10.2147/JIR.S451769
PMID: 38410420
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7031
DOI:10.2147/JIR.S451769