Evidence for glia-mediated, age-dependent remodeling of myelin at the axon initial segment.

التفاصيل البيبلوغرافية
العنوان:	Evidence for glia-mediated, age-dependent remodeling of myelin at the axon initial segment.
المؤلفون:	Furusho M; Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA., Terasaki M; Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.
المصدر:	The Journal of comparative neurology [J Comp Neurol] 2024 Feb; Vol. 532 (2), pp. e25574.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2003-> : Hoboken, N.J. : Wiley-Liss Original Publication: Philadelphia Wistar Institute of Anatomy and Biology
مواضيع طبية MeSH:	Myelin Sheath/ultrastructure , Axon Initial Segment, Mice ; Animals ; Axons/ultrastructure ; Neurons ; Microscopy, Electron
مستخلص:	Due to its proximity to the axon initial segment (AIS), the paranode of the first myelin segment can influence the threshold for action potentials and how a neuron participates in a neuronal circuit. Using serial section electron microscopy, we examined its three-dimensional (3D) organization in the ventral horn of the mouse spinal cord. The myelin loops of postnatal day 18 mice resemble those at the node of Ranvier. However, in 3-month-old mice, 13 of 22 para-AIS showed 4 types of alteration: (A) A cytoplasmic foot process, with ultrastructural characteristics of an astrocyte, was interposed between the axolemma and the myelin loops. (B) A thin extension of the inner tongue was present between the foot process and axolemma. (C) The foot process was absent. The inner tongue extension was a broad lamella from which a thin extension reached beyond the loops and spiraled around axon. (D) One set of loops was adjacent to the axon, and another was further back and underlain by compact myelin. We suggest that (A)-(C) are steps in a progression toward (D). In this progression, a glial process displaces the original loops, the inner tongue reactivates and extends beneath the foot process, then wraps around the axon to form a new set of loops. This is the first study of the 3D organization of myelin at the AIS and provides evidence for glia-mediated age-dependent remodeling at this critical region. (© 2024 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.)
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معلومات مُعتمدة:	Connecticut Science Fund
فهرسة مساهمة:	Keywords: astrocyte; axon initial segment; myelin; node of Ranvier
تواريخ الأحداث:	Date Created: 20240227 Date Completed: 20240228 Latest Revision: 20240426
رمز التحديث:	20240426
DOI:	10.1002/cne.25574
PMID:	38411251
قاعدة البيانات:	MEDLINE

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تدمد:	1096-9861
DOI:	10.1002/cne.25574