دورية أكاديمية
Simulation of Full HIV Cluster Networks in a Nationally Representative Model Indicates Intervention Opportunities.
| العنوان: | Simulation of Full HIV Cluster Networks in a Nationally Representative Model Indicates Intervention Opportunities. |
|---|---|
| المؤلفون: | France AM; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and., Panneer N; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and., Farnham PG; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and., Oster AM; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and., Viguerie A; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and., Gopalappa C; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and.; University of Massachusetts Amherst, Amherst, MA. |
| المصدر: | Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2024 Apr 01; Vol. 95 (4), pp. 355-361. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999- |
| مواضيع طبية MeSH: | HIV-1*/genetics , HIV Infections*/diagnosis , HIV Infections*/epidemiology, Humans ; United States/epidemiology ; Cluster Analysis ; Computer Simulation ; Phylogeny |
| مستخلص: | Background: Clusters of rapid HIV transmission in the United States are increasingly recognized through analysis of HIV molecular sequence data reported to the National HIV Surveillance System. Understanding the full extent of cluster networks is important to assess intervention opportunities. However, full cluster networks include undiagnosed and other infections that cannot be systematically observed in real life. Methods: We replicated HIV molecular cluster networks during 2015-2017 in the United States using a stochastic dynamic network simulation model of sexual transmission of HIV. Clusters were defined at the 0.5% genetic distance threshold. Ongoing priority clusters had growth of ≥3 diagnoses/year in multiple years; new priority clusters first had ≥3 diagnoses/year in 2017. We assessed the full extent, composition, and transmission rates of new and ongoing priority clusters. Results: Full clusters were 3-9 times larger than detected clusters, with median detected cluster sizes in new and ongoing priority clusters of 4 (range 3-9) and 11 (range 3-33), respectively, corresponding to full cluster sizes with a median of 14 (3-74) and 94 (7-318), respectively. A median of 36.3% (range 11.1%-72.6%) of infections in the full new priority clusters were undiagnosed. HIV transmission rates in these clusters were >4 times the overall rate observed in the entire simulation. Conclusions: Priority clusters reflect networks with rapid HIV transmission. The substantially larger full extent of these clusters, high proportion of undiagnosed infections, and high transmission rates indicate opportunities for public health intervention and impact. Competing Interests: The authors have no other funding or conflicts of interest to disclose. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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| معلومات مُعتمدة: | CC999999 United States ImCDC Intramural CDC HHS; R01 AI127236 United States AI NIAID NIH HHS; Number R01AI127236 United States NH NIH HHS |
| تواريخ الأحداث: | Date Created: 20240227 Date Completed: 20240229 Latest Revision: 20240301 |
| رمز التحديث: | 20240301 |
| مُعرف محوري في PubMed: | PMC10901443 |
| DOI: | 10.1097/QAI.0000000000003367 |
| PMID: | 38412046 |
| قاعدة البيانات: | MEDLINE |
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