دورية أكاديمية
أعرض في EDS

The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.

التفاصيل البيبلوغرافية
العنوان: The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.
المؤلفون: Lee DH; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Bae WH; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Ha H; Institute of Endemic Diseases, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea., Kim WR; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Park EG; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Lee YJ; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Kim JM; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Shin HJ; Department of Integrated Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea., Kim HS; Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea. khs307@pusan.ac.kr.; Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, 46241, Republic of Korea. khs307@pusan.ac.kr.
المصدر: Scientific reports [Sci Rep] 2024 Feb 27; Vol. 14 (1), pp. 4723. Date of Electronic Publication: 2024 Feb 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: DNA, Z-Form* , MicroRNAs*/genetics , MicroRNAs*/metabolism, Humans ; DNA Transposable Elements/genetics ; Gene Expression ; Gene Expression Regulation
مستخلص: Z-DNA, a well-known non-canonical form of DNA involved in gene regulation, is often found in gene promoters. Transposable elements (TEs), which make up 45% of the human genome, can move from one location to another within the genome. TEs play various biological roles in host organisms, and like Z-DNA, can influence transcriptional regulation near promoter regions. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a critical role in the regulation of gene expression. Although TEs can generate Z-DNA and miRNAs can bind to Z-DNA, how these factors affect gene transcription has yet to be elucidated. Here, we identified potential Z-DNA forming sequence (ZFS), including TE-derived ZFS, in the promoter of prostaglandin reductase 1 (PTGR1) by data analysis. The transcriptional activity of these ZFS in PTGR1 was confirmed using dual-luciferase reporter assays. In addition, we discovered a novel ZFS-binding miRNA (miR-6867-5p) that suppressed PTGR1 expression by targeting to ZFS. In conclusion, these findings suggest that ZFS, including TE-derived ZFS, can regulate PTGR1 gene expression and that miR-6867-5p can suppress PTGR1 by interacting with ZFS.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Human genome; PTGR1; Transposable element; Z-DNA; microRNA
المشرفين على المادة: 0 (DNA Transposable Elements)
0 (DNA, Z-Form)
0 (MicroRNAs)
EC 1.1.1.- (leukotriene B4 12-hydroxydehydrogenase)
تواريخ الأحداث: Date Created: 20240227 Date Completed: 20240229 Latest Revision: 20240301
رمز التحديث: 20240301
مُعرف محوري في PubMed: PMC10899170
DOI: 10.1038/s41598-024-55332-x
PMID: 38413664
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-55332-x