دورية أكاديمية
أعرض في EDS

Global diversity of enterococci and description of 18 previously unknown species.

التفاصيل البيبلوغرافية
العنوان: Global diversity of enterococci and description of 18 previously unknown species.
المؤلفون: Schwartzman JA; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Department of Biology, University of Southern California, Los Angeles, CA 90089., Lebreton F; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Multidrug-Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, MD 20910., Salamzade R; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706., Shea T; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Martin MJ; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Multidrug-Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, MD 20910., Schaufler K; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; University of Greifswald, Institute of Pharmacy, Greifswald 17489, Germany.; Kiel University and University Medical Center Schleswig-Holstein, Institute of Infection Medicine, Kiel 24105, Germany., Urhan A; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Delft 2628XE, The Netherlands., Abeel T; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, Delft 2628XE, The Netherlands., Camargo ILBC; Laboratório de Epidemiologia e Microbiologia Moleculares, Departamento de Física e Ciências Interdisciplinares, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos - SP 13566-590, Brazil., Sgardioli BF; Laboratório de Epidemiologia e Microbiologia Moleculares, Departamento de Física e Ciências Interdisciplinares, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos - SP 13566-590, Brazil., Prichula J; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Federal University of Health Sciences of Porto Alegre, Porto Alegre - RS 90050-170, Brazil., Guedes Frazzon AP; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Department of Microbiology, Immunology and Parasitology, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90010-150, Brazil., Giribet G; Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138., Van Tyne D; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburg, PA 15213., Treinish G; Adventure Scientists, Bozeman, MT 59715., Innis CJ; New England Aquarium, Animal Health Department and Anderson Cabot Center for Ocean Life, Boston, MA 02110., Wagenaar JA; Department of Biomolecular Health Sciences, Utrecht University, Utrecht 3584 CS, The Netherlands., Whipple RM; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115., Manson AL; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Earl AM; Infectious Disease and Microbiome Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Gilmore MS; Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA 02144.; Department of Microbiology, Harvard Medical School, Boston, MA 02115.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 05; Vol. 121 (10), pp. e2310852121. Date of Electronic Publication: 2024 Feb 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Enterococcus faecium*/genetics , Gram-Positive Bacterial Infections*, Animals ; Humans ; Enterococcus/genetics ; Anti-Bacterial Agents/pharmacology ; Enterococcus faecalis/genetics ; Phylogeny ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial
مستخلص: Enterococci are gut microbes of most land animals. Likely appearing first in the guts of arthropods as they moved onto land, they diversified over hundreds of millions of years adapting to evolving hosts and host diets. Over 60 enterococcal species are now known. Two species, Enterococcus faecalis and Enterococcus faecium, are common constituents of the human microbiome. They are also now leading causes of multidrug-resistant hospital-associated infection. The basis for host association of enterococcal species is unknown. To begin identifying traits that drive host association, we collected 886 enterococcal strains from widely diverse hosts, ecologies, and geographies. This identified 18 previously undescribed species expanding genus diversity by >25%. These species harbor diverse genes including toxins and systems for detoxification and resource acquisition. Enterococcus faecalis and E. faecium were isolated from diverse hosts highlighting their generalist properties. Most other species showed a more restricted distribution indicative of specialized host association. The expanded species diversity permitted the Enterococcus genus phylogeny to be viewed with unprecedented resolution, allowing features to be identified that distinguish its four deeply rooted clades, and the entry of genes associated with range expansion such as B-vitamin biosynthesis and flagellar motility to be mapped to the phylogeny. This work provides an unprecedentedly broad and deep view of the genus Enterococcus , including insights into its evolution, potential new threats to human health, and where substantial additional enterococcal diversity is likely to be found.
Competing Interests: Competing interests statement:The authors declare no competing interest.
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معلومات مُعتمدة: F32 GM121005 United States GM NIGMS NIH HHS; P01 AI083214 United States AI NIAID NIH HHS; U19 AI110818 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Enterococcus; antibiotic resistance; genomics; global diversity; host microbe interaction
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10927581
DOI: 10.1073/pnas.2310852121
PMID: 38416678
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.2310852121