دورية أكاديمية
Outbreak investigation of Serratia marcescens bloodstream infection in an obstetric ward for high-risk pregnant women.
| العنوان: | Outbreak investigation of Serratia marcescens bloodstream infection in an obstetric ward for high-risk pregnant women. |
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| المؤلفون: | Kim S; Department of Internal Medicine, Division of Infectious Diseases, Pusan National University Yangsan Hospital, 20 Geumo-Ro, Mulgeum-Eup, Yangsan, 50612, Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Jung S; Infection Prevention Department, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Lee DH; Department of Obstetrics and Gynecology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.; Department of Obstetrics & Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea., Chang CL; Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Bae M; Department of Internal Medicine, Division of Infectious Diseases, Pusan National University Yangsan Hospital, 20 Geumo-Ro, Mulgeum-Eup, Yangsan, 50612, Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Kim AR; Department of Internal Medicine, Division of Infectious Diseases, Pusan National University Yangsan Hospital, 20 Geumo-Ro, Mulgeum-Eup, Yangsan, 50612, Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Lee SJ; Department of Internal Medicine, Division of Infectious Diseases, Pusan National University Yangsan Hospital, 20 Geumo-Ro, Mulgeum-Eup, Yangsan, 50612, Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea., Lim S; Department of Internal Medicine, Division of Infectious Diseases, Pusan National University Yangsan Hospital, 20 Geumo-Ro, Mulgeum-Eup, Yangsan, 50612, Republic of Korea. babopm@naver.com.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. babopm@naver.com.; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. babopm@naver.com. |
| المصدر: | BMC infectious diseases [BMC Infect Dis] 2024 Feb 28; Vol. 24 (1), pp. 266. Date of Electronic Publication: 2024 Feb 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Cross Infection*/epidemiology , Cross Infection*/microbiology , Serratia Infections*/epidemiology , Serratia Infections*/microbiology , Sepsis*/epidemiology , Bacteremia*/epidemiology , Bacteremia*/microbiology, Pregnancy ; Humans ; Female ; Infant, Newborn ; Pregnant Women ; Serratia marcescens/genetics ; Retrospective Studies ; Disease Outbreaks ; Hospitals ; Adenosine Triphosphate ; Intensive Care Units, Neonatal |
| مستخلص: | Background: Serratia marcescens is a gram-negative bacterium that is widespread in the environment. S. marcescens bacteremia can be fatal during pregnancy and cause persistent chorioamnionitis. This study reports an outbreak of Serratia marcescens bloodstream infection (BSI) among high-risk pregnant women in an obstetric ward. The purpose of this study is to report our experience with the usefulness of the ATP test in hospital environmental management and to confirm that bloodstream infections of patients with the same strain were correlated by WGS testing. Methods: This retrospective study collected the data of inpatients with S. marcescens bacteremia in obstetric ward for high-risk pregnant women from August 22, 2021, to October 14, 2021. We performed: an adenosine triphosphate (ATP) bioluminescence test in the environment with a high-contact area; environmental culture; on-site monitoring and staff education; and whole-genome sequencing (WGS) to evaluate genetic relationships among S. marcescens isolates. Results: S. marcescens BSI occurred in four consecutive patients. None of the patients had central venous catheters. An ATP bioluminescence test revealed that high-contact areas and areas for injection preparation were not clean (≥ 1000 relative light units). However, S. marcescens was not identified in the environmental cultures, likely due to intensive environmental cleaning and discarding of potentially contaminated specimens before the culture test. On-site monitoring and education were conducted for 1 month. There were no further reports of BSI until 6 months after the last patient was discharged. WGS performed on three isolates from three patients indicated that the isolated S. marcescens was likely from the same strain. Conclusions: We controlled an S. marcescens outbreak by improving environmental cleaning as well as education of and behavior changes in healthcare workers. Using the ATP bioluminescence test can provide feedback on environmental cleaning and education. WGS played a role in determining the spread of BSI caused by the same strain. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Serratia marcescens; Bloodstream infection; Hand hygiene; High-risk pregnancy; Infectious disease outbreaks; Whole-genome sequencing |
| المشرفين على المادة: | 8L70Q75FXE (Adenosine Triphosphate) |
| تواريخ الأحداث: | Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC10900556 |
| DOI: | 10.1186/s12879-024-09134-1 |
| PMID: | 38418981 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2334 |
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| DOI: | 10.1186/s12879-024-09134-1 |