دورية أكاديمية
Cross-modality Labeling Enables Noninvasive Capillary Quantification as a Sensitive Biomarker for Assessing Cardiovascular Risk.
العنوان: | Cross-modality Labeling Enables Noninvasive Capillary Quantification as a Sensitive Biomarker for Assessing Cardiovascular Risk. |
---|---|
المؤلفون: | Shi D; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China., Zhou Y; Centre for Medical Image Computing, University College London, London, UK., He S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China., Wagner SK; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Huang Y; Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China., Keane PA; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Ting DSW; Singapore National Eye Center, Singapore Eye Research Institute, and Duke-NUS Medical School, National University of Singapore, Singapore, Singapore., Zhang L; Faculty of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Zheng Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China., He M; School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China. |
المصدر: | Ophthalmology science [Ophthalmol Sci] 2023 Dec 05; Vol. 4 (3), pp. 100441. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier, B.V., [2021]- |
مستخلص: | Purpose: We aim to use fundus fluorescein angiography (FFA) to label the capillaries on color fundus (CF) photographs and train a deep learning model to quantify retinal capillaries noninvasively from CF and apply it to cardiovascular disease (CVD) risk assessment. Design: Cross-sectional and longitudinal study. Participants: A total of 90732 pairs of CF-FFA images from 3893 participants for segmentation model development, and 49229 participants in the UK Biobank for association analysis. Methods: We matched the vessels extracted from FFA and CF, and used vessels from FFA as labels to train a deep learning model (RMHAS-FA) to segment retinal capillaries using CF. We tested the model's accuracy on a manually labeled internal test set (FundusCapi). For external validation, we tested the segmentation model on 7 vessel segmentation datasets, and investigated the clinical value of the segmented vessels in predicting CVD events in the UK Biobank. Main Outcome Measures: Area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity for segmentation. Hazard ratio (HR; 95% confidence interval [CI]) for Cox regression analysis. Results: On the FundusCapi dataset, the segmentation performance was AUC = 0.95, accuracy = 0.94, sensitivity = 0.90, and specificity = 0.93. Smaller vessel skeleton density had a stronger correlation with CVD risk factors and incidence ( P < 0.01). Reduced density of small vessel skeletons was strongly associated with an increased risk of CVD incidence and mortality for women (HR [95% CI] = 0.91 [0.84-0.98] and 0.68 [0.54-0.86], respectively). Conclusions: Using paired CF-FFA images, we automated the laborious manual labeling process and enabled noninvasive capillary quantification from CF, supporting its potential as a sensitive screening method for identifying individuals at high risk of future CVD events. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. (© 2024 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology.) |
References: | Circulation. 2008 Feb 12;117(6):743-53. (PMID: 18212285) Atherosclerosis. 2018 Jan;268:215-224. (PMID: 29050745) IEEE Trans Med Imaging. 2004 Apr;23(4):501-9. (PMID: 15084075) Med Image Anal. 2021 Feb;68:101905. (PMID: 33385700) Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4299-4306. (PMID: 30372758) BMJ. 2018 Nov 7;363:k4247. (PMID: 30404896) Int J Biomed Imaging. 2013;2013:154860. (PMID: 24416040) Microcirculation. 2019 Oct;26(7):e12555. (PMID: 31066106) Eur Heart J. 2003 Jun;24(11):987-1003. (PMID: 12788299) IEEE Trans Image Process. 2020 May 08;:. (PMID: 32396087) Transl Vis Sci Technol. 2022 Jul 8;11(7):12. (PMID: 35833885) Circulation. 2017 May 30;135(22):e1054-e1091. (PMID: 28446515) Ophthalmol Sci. 2023 Jul 06;4(2):100363. (PMID: 37868792) Curr Eye Res. 2023 Sep;48(9):843-849. (PMID: 37246501) IEEE Trans Biomed Eng. 2012 Sep;59(9):2538-48. (PMID: 22736688) Front Cardiovasc Med. 2022 Mar 22;9:823436. (PMID: 35391847) EPMA J. 2023 Feb 13;14(1):73-86. (PMID: 36866161) Ann Intensive Care. 2020 Nov 12;10(1):152. (PMID: 33184724) Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):19. (PMID: 35142788) Circulation. 2014 Jun 24;129(25 Suppl 2):S49-73. (PMID: 24222018) Circulation. 2022 Jan 11;145(2):134-150. (PMID: 34743558) BMJ Open. 2019 Feb 21;9(2):e025077. (PMID: 30796124) Nat Rev Cardiol. 2019 Jul;16(7):379-381. (PMID: 31089264) J Med Imaging (Bellingham). 2017 Jan;4(1):014503. (PMID: 28217714) Sci Rep. 2020 Oct 7;10(1):16718. (PMID: 33028913) Geroscience. 2020 Dec;42(6):1499-1525. (PMID: 33011937) J Am Heart Assoc. 2022 Mar 15;11(6):e024226. (PMID: 35253475) Atherosclerosis. 2023 Sep;380:117196. (PMID: 37562159) J Clin Med. 2021 Jun 16;10(12):. (PMID: 34208770) Ophthalmol Sci. 2023 Sep 15;3(4):100401. (PMID: 38025160) Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:3391-4. (PMID: 22255067) IEEE Trans Med Imaging. 2016 Dec;35(12):2631-2644. (PMID: 27514039) J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. (PMID: 33309175) |
معلومات مُعتمدة: | MR/T019050/1 United Kingdom MRC_ Medical Research Council |
فهرسة مساهمة: | Keywords: Cardiovascular disease; Cross-modality labeling; RMHAS-FA; Retinal capillary quantification |
تواريخ الأحداث: | Date Created: 20240229 Latest Revision: 20240313 |
رمز التحديث: | 20240313 |
مُعرف محوري في PubMed: | PMC10899028 |
DOI: | 10.1016/j.xops.2023.100441 |
PMID: | 38420613 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2666-9145 |
---|---|
DOI: | 10.1016/j.xops.2023.100441 |