دورية أكاديمية
Sentinel node mapping in high-intermediate and high-risk endometrial cancer: Analysis of 5-year oncologic outcomes.
| العنوان: | Sentinel node mapping in high-intermediate and high-risk endometrial cancer: Analysis of 5-year oncologic outcomes. |
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| المؤلفون: | Cuccu I; Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy; Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Italy., Raspagliesi F; Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Malzoni M; Endoscopica Malzoni, Center for Advanced Endoscopic Gynecological Surgery, Avellino, Italy., Vizza E; Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCSS-Regina Elena National Cancer Institute, Rome, Italy., Papadia A; Department of Obstetrics and Gynecology, EOC-Civico Hospital, 6900, Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900, Lugano, Switzerland., Di Donato V; Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Italy., Giannini A; Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Italy., De Iaco P; Department of Obstetrics and Gynecology, Unit of Oncologic Gynecology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy., Perrone AM; Department of Obstetrics and Gynecology, Unit of Oncologic Gynecology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy., Plotti F; Department of Gynecology, Campus Bio-Medico University Hospital Foundation, Rome, Italy., Angioli R; Department of Gynecology, Campus Bio-Medico University Hospital Foundation, Rome, Italy., Casarin J; Department of Obstetrics and Gynecology, 'Filippo Del Ponte' Hospital, University of Insubria, Varese, Italy., Ghezzi F; Department of Obstetrics and Gynecology, 'Filippo Del Ponte' Hospital, University of Insubria, Varese, Italy., Cianci S; Department of Human Pathology of Adult and Childhood 'G. Barresi', Unit of Gynecology and Obstetrics, University of Messina, Messina, Italy., Vizzielli G; Department of Medical Area (DAME), University of Udine, Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Restaino S; Department of Medical Area (DAME), University of Udine, Clinic of Obstetrics and Gynecology, 'Santa Maria Della Misericordia' University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Petrillo M; Gynecologic and Obstetric Clinic, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy., Sorbi F; Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Florence, Italy., Multinu F; Gynecologic Oncology Program, European Institute of Oncology, Milan, Italy., Schivardi G; Gynecologic Oncology Program, European Institute of Oncology, Milan, Italy., De Vitis LA; Gynecologic Oncology Program, European Institute of Oncology, Milan, Italy., Falcone F; Endoscopica Malzoni, Center for Advanced Endoscopic Gynecological Surgery, Avellino, Italy., Lalli L; Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Berretta R; Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy., Mueller MD; Department of Gynecology and Obstetrics, Bern University Hospital, University of Bern, Bern, Switzerland., Tozzi R; Division of Women and Children's Health, Department of Gynaecology and Obstetrics, University of Padua, 35122, Padua, Italy., Chiantera V; Gynaecologic Oncology, Istituto Nazionale Tumori di Napoli IRCCS 'Fondazione G. Pascale', Naples, Italy., Benedetti Panici P; Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Italy., Fanfani F; Gynecologic Oncology Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy., Scambia G; Gynecologic Oncology Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy., Bogani G; Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. Electronic address: giorgiobogani@yahoo.it. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2024 Apr; Vol. 50 (4), pp. 108018. Date of Electronic Publication: 2024 Feb 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Endometrial Neoplasms*/pathology , Sentinel Lymph Node*/pathology, Female ; Humans ; Sentinel Lymph Node Biopsy/methods ; Retrospective Studies ; Lymph Node Excision/methods ; Neoplasm Staging ; Lymph Nodes/surgery ; Lymph Nodes/pathology |
| مستخلص: | Objective: To assess 5-year oncologic outcomes of apparent early-stage high-intermediate and high-risk endometrial cancer undergoing sentinel node mapping versus systematic lymphadenectomy. Methods: This is a multi-institutional retrospective, propensity-matched study evaluating data of high-intermediate and high-risk endometrial cancer (according to ESGO/ESTRO/ESP guidelines) undergoing sentinel node mapping versus systematic pelvic lymphadenectomy (with and without para-aortic lymphadenectomy). Survival outcomes were assessed using Kaplan-Meier and Cox proportional hazard methods. Results: Overall, the charts of 242 patients with high-intermediate and high-risk endometrial cancer were retrieved. Data on 73 (30.1%) patients undergoing hysterectomy plus sentinel node mapping were analyzed. Forty-two (57.5%) and 31 (42.5%) patients were classified in the high-intermediate and high-risk groups, respectively. Unilateral sentinel node mapping was achieved in all patients. Bilateral mapping was achieved in 67 (91.7%) patients. Three (4.1%) patients had site-specific lymphadenectomy (two pelvic areas only and one pelvic plus para-aortic area), while adjunctive nodal dissection was omitted in the hemipelvis of the other three (4.1%) patients. Sentinel nodes were detected in the para-aortic area in eight (10.9%) patients. Twenty-four (32.8%) patients were diagnosed with nodal disease. A propensity-score matching was used to compare the aforementioned group of patients undergoing sentinel node mapping with a group of patients undergoing lymphadenectomy. Seventy patient pairs were selected (70 having sentinel node mapping vs. 70 having lymphadenectomy). Patients undergoing sentinel node mapping experienced similar 5-year disease-free survival (HR: 1.233; 95%CI: 0.6217 to 2.444; p = 0.547, log-rank test) and 5-year overall survival (HR: 1.505; 95%CI: 0.6752 to 3.355; p = 0.256, log-rank test) than patients undergoing lymphadenectomy. Conclusions: Sentinel node mapping does not negatively impact 5-year outcomes of high-intermediate and high-risk endometrial cancer. Further prospective studies are warranted. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Endometrial cancer; High-risk; Intermediate-high risk; Sentinel node mapping |
| تواريخ الأحداث: | Date Created: 20240301 Date Completed: 20240401 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| DOI: | 10.1016/j.ejso.2024.108018 |
| PMID: | 38428106 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2024.108018 |