دورية أكاديمية
Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways.
| العنوان: | Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways. |
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| المؤلفون: | Nabil G; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. Electronic address: Gazal_nabil@cu.edu.eg., Ahmed YH; Department of Cytology & Histology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Ahmed O; Department of Cytology & Histology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Milad SS; Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Hisham M; Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Rafat M; Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Atia M; Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Shokry AA; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. Electronic address: ayaabdelsalam333@cu.edu.eg. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 Jun 12; Vol. 327, pp. 117970. Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Stomach Ulcer*/chemically induced , Stomach Ulcer*/drug therapy , Stomach Ulcer*/pathology , Anti-Ulcer Agents*/pharmacology , Anti-Ulcer Agents*/therapeutic use, Mice ; Animals ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/metabolism ; Omeprazole/pharmacology ; Omeprazole/therapeutic use ; Ethanol/pharmacology ; Cytokines/metabolism ; Gastric Mucosa |
| مستخلص: | Ethnopharmacological Relevance: Solenostemma argel is widely distributed in Africa & Asia with traditional usage in alleviating abdominal colic, aches, & cramps. This plant is rich in phytochemicals, which must be explored for its pharmacological effects. Purpose: Peptic Ulcer Disease (PUD) is the digestion of the digestive tube. PUD not only interferes with food digestion & nutrient absorption, damages one of the largest defensive barriers against pathogenic micro-organisms, but also impedes drug absorption & bioavailability, rendering the oral route, the most convenient way, ineffective. Omeprazole, one of the indispensable cost-effective proton-pump inhibitors (PPIs) extensively prescribed to control PUD, is showing growing apprehensions toward multiple drug interactions & side effects. Hence, finding a natural alternative with Omeprazole-like activity & limited side effects is a medical concern. Study Design: Therefore, we present Stemmoside C as a new gastroprotective phytochemical agent isolated from Solenostemma argel to be tested in upgrading doses against ethanol-induced gastric ulcers in mice compared to negative, positive, & reference Omeprazole groups. Methods: We carried out in-depth pharmacological & histopathological studies to determine the possible mechanistic pathway. Results: Our results showed that Stemmoside C protected the stomach against ethanol-induced gastric ulcers parallel to Omeprazole. Furthermore, the mechanistic studies revealed that Stemmoside C produced its effect using an orchestrated array of different mechanisms. Stemmoside C stimulates stomach defense by increasing COX-2, PGE-2, NO, & TFF-1 healing factors, IL-10 anti-inflammatory cytokine, & Nrf-2 & HO-1 anti-oxidant pathways. It also suppresses stomach ulceration by inhibiting leucocyte recruitment, especially neutrophils, leading to subsequent inhibition of NF-κBp65, TNF-α, IL-1β, & iNOS pro-inflammatory cytokines & JAK-1/STAT-3 inflammation-induced carcinogenicity cascade in addition to MMP-9 responsible for tissue degradation. Conclusion: These findings cast light on Stemmoside C's clinical application against gastric ulcer progression, recurrence, & tumorigenicity & concurrently with chemotherapy. Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Gastric ulcer; JAK-1/STAT-3; Nrf-2/HO-1; Solenostemma argel; Stemmoside C |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Anti-Ulcer Agents) KG60484QX9 (Omeprazole) 3K9958V90M (Ethanol) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20240301 Date Completed: 20240401 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| DOI: | 10.1016/j.jep.2024.117970 |
| PMID: | 38428660 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2024.117970 |