دورية أكاديمية
Efficacy and safety of 1064-nm fractional picosecond laser for the treatment of postmastectomy scars in transgender men: A randomized controlled trial.
| العنوان: | Efficacy and safety of 1064-nm fractional picosecond laser for the treatment of postmastectomy scars in transgender men: A randomized controlled trial. |
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| المؤلفون: | Rutnin S; Division of Dermatology, Mahidol University, Bangkok, Thailand., Yongpisarn T; Division of Dermatology, Mahidol University, Bangkok, Thailand., Sakpuwadol N; Division of Dermatology, Mahidol University, Bangkok, Thailand., Namasondhi A; Division of Dermatology, Mahidol University, Bangkok, Thailand., Pomsoong C; Division of Dermatology, Mahidol University, Bangkok, Thailand., Rattananukrom T; Division of Dermatology, Mahidol University, Bangkok, Thailand., Thadanipon K; Division of Dermatology, Mahidol University, Bangkok, Thailand.; Department of Clinical Epidemiology and Biostatistics, Mahidol University, Bangkok, Thailand. |
| المصدر: | Lasers in surgery and medicine [Lasers Surg Med] 2024 Apr; Vol. 56 (4), pp. 337-345. Date of Electronic Publication: 2024 Mar 04. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8007168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9101 (Electronic) Linking ISSN: 01968092 NLM ISO Abbreviation: Lasers Surg Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York : Alan Liss |
| مواضيع طبية MeSH: | Breast Neoplasms*/surgery , Cicatrix, Hypertrophic*/pathology , Lasers, Gas* , Transgender Persons*, Humans ; Male ; Cicatrix/etiology ; Cicatrix/radiotherapy ; Cicatrix/surgery ; Hemoglobins ; Hypertrophy/surgery ; Lasers ; Mastectomy ; Melanins ; Quality of Life ; Treatment Outcome ; Female |
| مستخلص: | Objectives: Subcutaneous mastectomy is a crucial component of gender affirmation therapy for transgender men (TM), but the scars that result from this procedure can frequently impair their quality of life. This study aimed to assess the efficacy and safety of 1064-nm fractional picosecond laser (FxPico) treatment for hypertrophic and atrophic postmastectomy scars in TM. Methods: Twenty-two patients with a total of 35 pairs of bilateral symmetric mastectomy scars were enrolled. One of each pair of symmetric scars was randomly assigned to receive four FxPico treatments at 4-week intervals. All scars were evaluated using the modified Vancouver Scar Scale (mVSS) and three-dimensional imaging for scar roughness, melanin index, and hemoglobin index before each treatment session and at 1, 3, and 6 months following the last treatment. Additionally, participant-rated scar satisfaction (PSS) and scar improvement (Global Assessment Score, GAS), as well as adverse events were recorded. Results: During the 6-month follow-up period after the end of laser treatment sessions, the treated scars showed significant reductions in the mVSS compared to the untreated controls (p < 0.001), whereas the melanin index and hemoglobin index were not significantly different. Subgroup analysis of hypertrophic scars demonstrated statistically significant reductions in mVSS at 1 (p = 0.003) and 3 months (p = 0.041) after the end of laser treatments. PSS was significantly higher on the laser-treated scars than the controls (p = 0.008), and a participant-rated GAS of 2.95 ± 0.65 was found. There were no serious adverse events reported. Conclusions: 1064-nm FxPico could be utilized to treat mastectomy scars among TM, particularly the hypertrophic type. (© 2024 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: atrophic scar; hypertrophic scar; picosecond laser; postmastectomy scar; transgender men; transmasculine individuals; transmen |
| المشرفين على المادة: | 0 (Hemoglobins) 0 (Melanins) |
| تواريخ الأحداث: | Date Created: 20240304 Date Completed: 20240415 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1002/lsm.23775 |
| PMID: | 38436118 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-9101 |
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| DOI: | 10.1002/lsm.23775 |