دورية أكاديمية
A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy.
| العنوان: | A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy. |
|---|---|
| المؤلفون: | Lao Z; Department of Haematology, Singapore General Hospital, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ding LW; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Pathology, National University of Singapore, Nanomedicine Translational Research Programme, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sun QY; Department of Haematology, Singapore General Hospital, Singapore, Singapore.; Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore., Jia L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Yan B; Department of Laboratory Medicine, National University Hospital, Singapore, Singapore., Ng AY; MGI Tech Singapore. Ltd., Singapore, Singapore., Capinpin SM; Healthy Longitudinal Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University of Singapore, Singapore, Singapore., Wang R; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Ying L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Center for Cancer Research and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National University Cancer Institute, National University Health System, Singapore, Singapore., Koeffler HP; National University Cancer Institute, National University Health System, Singapore, Singapore.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Koh WP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Yang H; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biomedical Informatics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Goh YT; Department of Haematology, Singapore General Hospital, Singapore, Singapore., Grigoropoulos N; Department of Haematology, Singapore General Hospital, Singapore, Singapore. |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 15; Vol. 30 (10), pp. 2170-2180. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مواضيع طبية MeSH: | DNA Methylation* , Myelodysplastic Syndromes*/genetics , Myelodysplastic Syndromes*/blood , Myelodysplastic Syndromes*/diagnosis , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/blood , Leukemia, Myeloid, Acute*/diagnosis, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Aged ; Adult ; Epigenesis, Genetic ; Singapore/epidemiology ; Mutation ; Genetic Predisposition to Disease ; Risk Factors |
| مستخلص: | Purpose: DNA methylation alterations are widespread in acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), some of which appear to have evolved independently of somatic mutations in epigenetic regulators. Although the presence of somatic mutations in peripheral blood can predict the risk of development of AML and MDS, its accuracy remains unsatisfactory. Experimental Design: We performed global DNA methylation profiling in a case control study nested within the Singapore Chinese Health Study to evaluate whether DNA methylation alterations were associated with AML/MDS development. Targeted deep sequencing and methylated DNA immunoprecipitation sequencing (MeDIP-seq) were performed on peripheral blood collected a median of 9.9 years before diagnosis of AML or MDS, together with age-matched still-healthy individuals as controls. Results: Sixty-six individuals who developed AML or MDS displayed significant DNA methylation changes in the peripheral blood compared with 167 age- and gender-matched controls who did not develop AML/MDS during the follow-up period. Alterations in methylation in the differentially methylation regions were associated with increased odds of developing AML/MDS. Conclusions: The epigenetic changes may be acquired independently and before somatic mutations that are relevant for AML/MDS development. The association between methylation changes and the risk of pre-AML/MDS in these individuals was considerably stronger than somatic mutations, suggesting that methylation changes could be used as biomarkers for pre-AML/MDS screening. (©2024 American Association for Cancer Research.) |
| References: | Haematologica. 2013 Dec;98(12):1912-20. (PMID: 23831920) Blood. 2020 Oct 1;136(14):1599-1605. (PMID: 32736382) Mol Cell. 2013 Jan 24;49(2):359-367. (PMID: 23177740) Sci Adv. 2018 Nov 07;4(11):eaau6986. (PMID: 30417100) Leukemia. 2022 Apr;36(4):1185-1188. (PMID: 34845315) Blood. 2022 Jan 6;139(1):87-103. (PMID: 34320176) Bioinformatics. 2009 Jul 15;25(14):1754-60. (PMID: 19451168) Leukemia. 2014 Jan;28(1):1-14. (PMID: 23958917) N Engl J Med. 2014 Dec 25;371(26):2477-87. (PMID: 25426838) Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677) Nat Commun. 2022 Sep 12;13(1):5350. (PMID: 36097025) Cell. 2012 Jul 20;150(2):264-78. (PMID: 22817890) Nat Commun. 2016 Aug 22;7:12484. (PMID: 27546487) Nat Genet. 2022 Aug;54(8):1155-1166. (PMID: 35835912) Blood. 2018 Feb 1;131(5):496-504. (PMID: 29141946) Anticancer Agents Med Chem. 2020;20(18):2207-2215. (PMID: 32664845) Oncogene. 2016 May 12;35(19):2453-64. (PMID: 26279301) Cancer Res. 2007 Dec 15;67(24):11481-6. (PMID: 18089774) Nat Med. 2019 Mar;25(3):517-525. (PMID: 30664780) Leukemia. 2017 Jan;31(1):1-10. (PMID: 27389053) Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3949-54. (PMID: 17360458) Cell. 2007 Feb 23;128(4):683-92. (PMID: 17320506) Leuk Res. 2012 Sep;36(9):1128-33. (PMID: 22749068) Genes Dev. 2015 May 1;29(9):910-22. (PMID: 25886910) Cell Stem Cell. 2018 Feb 1;22(2):157-170. (PMID: 29395053) Nat Genet. 2023 Sep;55(9):1523-1530. (PMID: 37620601) MedComm (2020). 2023 Jun 21;4(4):e294. (PMID: 37361897) Nature. 2014 Feb 20;506(7488):328-33. (PMID: 24522528) Genome Biol. 2008;9(9):R137. (PMID: 18798982) Nat Med. 2014 Dec;20(12):1472-8. (PMID: 25326804) Epigenetics. 2012 Feb;7(2):201-7. (PMID: 22395470) Nat Commun. 2017 Mar 17;8:14617. (PMID: 28303888) Nat Med. 2020 Jul;26(7):1041-1043. (PMID: 32572266) J Biol Chem. 2014 Mar 28;289(13):8865-80. (PMID: 24550385) Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10522-7. (PMID: 22689993) Nat Commun. 2020 Jul 21;11(1):3475. (PMID: 32694610) N Engl J Med. 2014 Dec 25;371(26):2488-98. (PMID: 25426837) BMC Med Genomics. 2020 Feb 24;13(Suppl 3):27. (PMID: 32093698) Nature. 2018 Nov;563(7732):579-583. (PMID: 30429608) Blood. 2021 Sep 30;138(13):1137-1147. (PMID: 33951732) Genome Res. 2010 Oct;20(10):1441-50. (PMID: 20802089) Nature. 2018 Jul;559(7714):400-404. (PMID: 29988082) Leukemia. 2017 Mar;31(3):534-542. (PMID: 27899806) Cell Death Discov. 2023 Jul 28;9(1):274. (PMID: 37507383) Nat Med. 2018 Jul;24(7):1015-1023. (PMID: 29988143) Blood. 2023 Apr 27;141(17):2156-2159. (PMID: 36634304) Nature. 2020 Oct;586(7831):763-768. (PMID: 33057201) Nature. 2012 Jan 11;481(7382):506-10. (PMID: 22237025) Clin Epigenetics. 2019 Mar 27;11(1):54. (PMID: 30917865) Cell. 2017 Feb 23;168(5):801-816.e13. (PMID: 28215704) Blood. 2015 Jul 2;126(1):9-16. (PMID: 25931582) |
| معلومات مُعتمدة: | R01 CA144034 United States CA NCI NIH HHS; MOH-OFIRG21nov-0007 National Medical Research Council (NMRC); NMRC/TA/0051/2016 National Medical Research Council (NMRC); NMRC/Fellowship/0036/2016 National Medical Research Council (NMRC); UM1 CA182876 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20240304 Date Completed: 20240515 Latest Revision: 20240517 |
| رمز التحديث: | 20240517 |
| مُعرف محوري في PubMed: | PMC11096012 |
| DOI: | 10.1158/1078-0432.CCR-22-3804 |
| PMID: | 38437679 |
| قاعدة البيانات: | MEDLINE |
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