دورية أكاديمية
Prognostic nomogram for predicting the overall survival rate of patients with uterine clear-cell carcinoma: Based on SEER database.
| العنوان: | Prognostic nomogram for predicting the overall survival rate of patients with uterine clear-cell carcinoma: Based on SEER database. |
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| المؤلفون: | Huang T; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China., Lu F; Emergency Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China. |
| المصدر: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 Aug; Vol. 166 (2), pp. 707-717. Date of Electronic Publication: 2024 Mar 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Malden, MA : Wiley Original Publication: [New York, NY] Hoeber Medical Division, Harper & Row, [c1969- |
| مواضيع طبية MeSH: | Nomograms* , SEER Program* , Uterine Neoplasms*/mortality , Uterine Neoplasms*/therapy , Uterine Neoplasms*/pathology , Neoplasm Staging* , Adenocarcinoma, Clear Cell*/mortality , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/therapy, Humans ; Female ; Middle Aged ; Aged ; Adult ; Prognosis ; Risk Factors ; Survival Rate ; United States/epidemiology ; Retrospective Studies |
| مستخلص: | Objective: To evaluate the risk factors for uterine clear-cell carcinoma (UCCC) and construct nomograms predicting 1-, 3-, and 5-year overall survival rates of patients with UCCC. Methods: The demographic and clinical information of 1674 patients diagnosed with UCCC between 2004 and 2015, including age, race, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, and details of surgery and radiotherapy/chemotherapy, was collected from the Surveillance, Epidemiology, and End Results (SEER) database. After excluding patients with unknown AJCC stage, race, marital status, or lymph node information, 1469 patients remained. Risk factors were determined using univariate and multivariate analyses, and nomograms were developed to predict 1-, 3-, and 5-year overall survival of UCCC. Various indicators were used to evaluate the performance of the nomogram, such as the C-index, net classification improvement (NRI) and decision curve analysis (DCA). Results: Age, log odds of positive lymph nodes, AJCC stage, surgery status, and chemotherapy status were independent risk factors for UCCC. The C-indexes of the training group and AJCC stage groups were 0.771 and 0.697, respectively. The results for the area under the receiver operating characteristics curve, NRI, and calibration curves indicated that the nomogram had good predictive ability. DCA revealed that the nomogram had greater clinical applicability than AJCC stage alone. Internal validation using the validation cohort also demonstrated that this nomogram had good predictive performance. Conclusion: A new nomogram comprising a combination of demographic and clinical characteristics provided better survival predictions than the AJCC staging system alone, which will facilitate prognostic assessments and clinical decision-making. (© 2024 International Federation of Gynecology and Obstetrics.) |
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| فهرسة مساهمة: | Keywords: nomogram; overall survival; prognostic model; uterine clear‐cell carcinoma |
| تواريخ الأحداث: | Date Created: 20240306 Date Completed: 20240717 Latest Revision: 20240717 |
| رمز التحديث: | 20240718 |
| DOI: | 10.1002/ijgo.15456 |
| PMID: | 38444201 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3479 |
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| DOI: | 10.1002/ijgo.15456 |