دورية أكاديمية
Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
| العنوان: | Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury. |
|---|---|
| المؤلفون: | Buse M; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Cheng M; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany., Jankowski V; Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany., Lellig M; Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany., Sterzer V; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Strieder T; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Leuchtle K; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Martin IV; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Seikrit C; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Brinkkoettter P; Department II of Internal Medicine and Centre for Molecular Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Crispatzu G; Department II of Internal Medicine and Centre for Molecular Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Floege J; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Boor P; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany., Speer T; Medical Clinic 4, Nephrology, University of Frankfurt und Goethe-University Frankfurt, Frankfurt am Main, Germany., Kramann R; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands., Ostendorf T; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Moeller MJ; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Costa IG; Institute for Computational Genomics, RWTH Aachen University Hospital, Aachen, Germany., Stamellou E; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany. |
| المصدر: | IScience [iScience] 2024 Feb 16; Vol. 27 (3), pp. 109255. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| مستخلص: | Tubular injury is the hallmark of acute kidney injury (AKI) with a tremendous impact on patients and health-care systems. During injury, any differentiated proximal tubular cell (PT) may transition into a specific injured phenotype, so-called "scattered tubular cell" (STC)-phenotype. To understand the fate of this specific phenotype, we generated transgenic mice allowing inducible, reversible, and irreversible tagging of these cells in a murine AKI model, the unilateral ischemia-reperfusion injury (IRI). For lineage tracing, we analyzed the kidneys using single-cell profiling during disease development at various time points. Labeled cells, which we defined by established endogenous markers, already appeared 8 h after injury and showed a distinct expression set of genes. We show that STCs re-differentiate back into fully differentiated PTs upon the resolution of the injury. In summary, we show the dynamics of the phenotypic transition of PTs during injury, revealing a reversible transcriptional program as an adaptive response during disease. Competing Interests: The authors declare no competing interests. (© 2024 The Author(s).) |
| References: | Mol Brain. 2009 Nov 28;2:37. (PMID: 19943951) Neurology. 2018 Nov 6;91(19):e1799-e1808. (PMID: 30305446) Nucleic Acids Res. 2002 Dec 1;30(23):e134. (PMID: 12466566) J Am Soc Nephrol. 2007 Apr;18(4):1292-8. (PMID: 17314324) Acta Pharmacol Sin. 2022 Jan;43(1):39-49. (PMID: 33767380) Kidney Int. 2012 Mar;81(5):442-8. (PMID: 22113526) Am J Pathol. 2012 Oct;181(4):1236-49. (PMID: 22885106) JCI Insight. 2017 Sep 21;2(18):. (PMID: 28931758) Int J Mol Sci. 2020 Dec 31;22(1):. (PMID: 33396437) J Clin Invest. 2013 Sep;123(9):4023-35. (PMID: 23979159) J Am Soc Nephrol. 1997 Nov;8(11):1647-57. (PMID: 9355067) Front Cardiovasc Med. 2022 Apr 14;9:833642. (PMID: 35498043) Microvasc Res. 2009 Jan;77(1):4-7. (PMID: 18938184) Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F94-F102. (PMID: 27194715) J Am Soc Nephrol. 2023 Apr 1;34(4):554-571. (PMID: 36735940) Allergol Immunopathol (Madr). 2023 Mar 01;51(2):99-110. (PMID: 36916093) Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):. (PMID: 34183416) Int J Mol Sci. 2022 Sep 17;23(18):. (PMID: 36142787) J Mol Med (Berl). 2013 Sep;91(9):1095-107. (PMID: 23636508) Nat Commun. 2022 Jul 11;13(1):4018. (PMID: 35821371) J Clin Invest. 2015 Apr;125(4):1620-36. (PMID: 25751064) J Pharmacol Exp Ther. 2003 Mar;304(3):905-12. (PMID: 12604664) Front Physiol. 2022 Jun 08;13:933677. (PMID: 35755431) J Am Soc Nephrol. 2006 Sep;17(9):2443-56. (PMID: 16885410) Cell Rep. 2016 Feb 2;14(4):861-871. (PMID: 26776520) Am J Physiol. 1999 Sep;277(3):F454-63. (PMID: 10484529) J Pathol. 2013 Apr;229(5):645-59. (PMID: 23124355) Elife. 2021 Jul 19;10:. (PMID: 34279220) Annu Rev Cell Dev Biol. 2005;21:605-31. (PMID: 16212509) Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1527-32. (PMID: 24127583) Science. 2004 Jan 16;303(5656):359-63. (PMID: 14671312) Clin J Am Soc Nephrol. 2013 Mar;8(3):476-83. (PMID: 23471414) Nephrol Dial Transplant. 2021 Nov 9;36(11):1968-1975. (PMID: 32666119) Nat Rev Mol Cell Biol. 2004 Oct;5(10):836-47. (PMID: 15459664) J Am Soc Nephrol. 2017 Jan;28(1):377-387. (PMID: 27297949) Cell. 2018 Jul 26;174(3):716-729.e27. (PMID: 29961576) Am J Physiol Renal Physiol. 2020 Aug 1;319(2):F149-F154. (PMID: 32567347) Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1533-8. (PMID: 24474779) Kidney Int. 2002 Nov;62(5):1539-49. (PMID: 12371954) Nephron Exp Nephrol. 2007;105(1):e33-40. (PMID: 17108708) J Am Soc Nephrol. 2005 Nov;16(11):3365-70. (PMID: 16177006) J Clin Invest. 2009 Jul;119(7):1794-805. (PMID: 19587454) Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15874-15883. (PMID: 32571916) J Am Soc Nephrol. 2020 Dec;31(12):2793-2814. (PMID: 33115917) Am J Nephrol. 2016;43(5):305-17. (PMID: 27166158) Nat Genet. 1999 Jan;21(1):70-1. (PMID: 9916792) J Am Soc Nephrol. 2007 Dec;18(12):3128-38. (PMID: 17978305) Am J Physiol. 1979 Oct;237(4):F319-25. (PMID: 495725) J Cell Sci. 2009 Jan 15;122(Pt 2):171-7. (PMID: 19118209) Cell Rep. 2022 Nov 8;41(6):111610. (PMID: 36351395) J Clin Invest. 1994 May;93(5):2175-88. (PMID: 7910173) Kidney Int. 2016 Apr;89(4):792-808. (PMID: 26924053) J Am Soc Nephrol. 2022 Jun;33(6):1173-1181. (PMID: 35296554) Hum Pathol. 2014 Feb;45(2):382-93. (PMID: 24439225) J Am Soc Nephrol. 2009 Feb;20(2):333-43. (PMID: 19092119) Cell Rep. 2015 Aug 25;12(8):1325-38. (PMID: 26279573) J Am Soc Nephrol. 2009 Jan;20(1):223-8. (PMID: 19020007) |
| فهرسة مساهمة: | Keywords: Cell biology; Nephrology |
| تواريخ الأحداث: | Date Created: 20240306 Latest Revision: 20240307 |
| رمز التحديث: | 20240307 |
| مُعرف محوري في PubMed: | PMC10914483 |
| DOI: | 10.1016/j.isci.2024.109255 |
| PMID: | 38444605 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!