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Pyrene-Appended Boronic Acids on Graphene Foam Electrodes Provide Quantum Capacitance-Based Molecular Sensors for Lactate.

التفاصيل البيبلوغرافية
العنوان: Pyrene-Appended Boronic Acids on Graphene Foam Electrodes Provide Quantum Capacitance-Based Molecular Sensors for Lactate.
المؤلفون: Wikeley SM; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Przybylowski J; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Gardiner JE; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., James TD; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China., Fletcher PJ; Imaging Facility, University of Bath, Bath BA2 7AY, U.K., Isaacs MA; HarwellXPS, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Campus, Didcot OX11 0FA, U.K.; Department of Chemistry, University College London, London WC1H 0AJ, U.K., Lozano-Sanchez P; Integrated Graphene Ltd., Euro House, Wellgreen Place, Stirling FK8 2DJ, U.K., Caffio M; Integrated Graphene Ltd., Euro House, Wellgreen Place, Stirling FK8 2DJ, U.K., Marken F; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
المصدر: ACS sensors [ACS Sens] 2024 Mar 22; Vol. 9 (3), pp. 1565-1574. Date of Electronic Publication: 2024 Mar 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, [2016]-
مواضيع طبية MeSH: Lactic Acid*/analysis , Graphite*/chemistry, Humans ; Boronic Acids/chemistry ; Sweat/chemistry ; Electrodes
مستخلص: Molecular recognition and sensing can be coupled to interfacial capacitance changes on graphene foam surfaces linked to double layer effects and coupled to enhanced quantum capacitance. 3D graphene foam film electrodes (Gii-Sens; thickness approximately 40 μm; roughness factor approximately 100) immersed in aqueous buffer media exhibit an order of magnitude jump in electrochemical capacitance upon adsorption of a charged molecular receptor based on pyrene-appended boronic acids (here, 4-borono-1-(pyren-2-ylmethyl)pyridin-1-ium bromide, or abbreviated T1). This pyrene-appended pyridinium boronic acid receptor is employed here as a molecular receptor for lactate. In the presence of lactate and at pH 4.0 (after pH optimization), the electrochemical capacitance (determined by impedance spectroscopy) doubles again. Lactic acid binding is expressed with a Hillian binding constant ( K lactate = 75 mol -1 dm 3 and α = 0.8 in aqueous buffer, K lactate = 460 mol -1 dm 3 and α = 0.8 in artificial sweat, and K lactate = 340 mol -1 dm 3 and α = 0.65 in human serum). The result is a selective molecular probe response for lactic acid with LoD = 1.3, 1.4, and 1.8 mM in aqueous buffer media (pH 4.0), in artificial sweat (adjusted to pH 4.7), and in human serum (pH adjusted to 4.0), respectively. The role of the pyrene-appended boronic acid is discussed based on the double layer structure and quantum capacitance changes. In the future, this new type of molecular capacitance sensor could provide selective enzyme-free analysis without analyte consumption for a wider range of analytes and complex environments.
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فهرسة مساهمة: Keywords: graphene foam; lactate sensor; molecular capacitance; quantum capacitance; wearable sensor
المشرفين على المادة: 33X04XA5AT (Lactic Acid)
7782-42-5 (Graphite)
0 (Boronic Acids)
تواريخ الأحداث: Date Created: 20240306 Date Completed: 20240325 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC10964244
DOI: 10.1021/acssensors.4c00027
PMID: 38447101
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-3694
DOI:10.1021/acssensors.4c00027