دورية أكاديمية
Fibroblast function recovery through rejuvenation effect of nanovesicles extracted from human adipose-derived stem cells irradiated with red light.
| العنوان: | Fibroblast function recovery through rejuvenation effect of nanovesicles extracted from human adipose-derived stem cells irradiated with red light. |
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| المؤلفون: | Hyun J; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Eom J; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Im J; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim YJ; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Seo I; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim SW; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Im GB; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Surgery, Harvard Medical School, Boston, MA, 02115 USA., Kim YH; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Lee DH; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Park HS; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Yun DW; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim DI; Division of Vascular Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, South Korea., Yoon JK; Department of Systems Biotechnology, Chung-Ang University, Anseong 4726, Republic of Korea., Um SH; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Yang DH; Department of Medical Life Sciences, College of Medicine, Institute of Cell and Tissue Engineering, The Catholic University of Korea, Seoul, Republic of Korea., Bhang SH; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: sukhobhang@skku.edu. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Apr; Vol. 368, pp. 453-465. Date of Electronic Publication: 2024 Mar 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Rejuvenation* , Red Light*, Humans ; Recovery of Function ; Stem Cells ; Fibroblasts |
| مستخلص: | Fibroblasts (hDFs) are widely employed for skin regeneration and the treatment of various skin disorders, yet research were rarely investigated about restoration of diminished therapeutic efficacy due to cell senescence. The application of stem cell and stem cell-derived materials, exosomes, were drawn attention for the restoration functionality of fibroblasts, but still have limitation for unintended side effect or low yield. To advance, stem cell-derived nanovesicle (NV) have developed for effective therapeutic reagents with high yield and low risk. In this study, we have developed a method using red light irradiated human adipose-derived stem cells (hADSCs) derived NV (R-NVs) for enhancing the therapeutic efficacy and rejuvenating hDFs. Through red light irradiation, we were able to significantly increase the content of stemness factors and angiogenic biomolecules in R-NVs. Treatment with these R-NVs was found to enhance the migration ability and leading to rejuvenation of old hDFs to levels similar to those of young hDFs. In subsequent in vivo experiments, the treatment of old hDFs with R-NVs demonstrated a superior skin wound healing effect, surpassing that of young hDFs. In summary, this study successfully induced rejuvenation and leading to increased therapeutic efficacy to R-NVs treated old hDFs previously considered as biowaste. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Fibroblast; Fibroblast rejuvenation; Human adipose-derived mesenchymal stem cell; Photobiomodulation; Stem cell nanovesicle; Stem cell therapy; Wound closing |
| تواريخ الأحداث: | Date Created: 20240306 Date Completed: 20240410 Latest Revision: 20240410 |
| رمز التحديث: | 20240410 |
| DOI: | 10.1016/j.jconrel.2024.02.047 |
| PMID: | 38447812 |
| قاعدة البيانات: | MEDLINE |
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