دورية أكاديمية
Brain tumour microstructure is associated with post-surgical cognition.
| العنوان: | Brain tumour microstructure is associated with post-surgical cognition. |
|---|---|
| المؤلفون: | Aznarez-Sanado M; School of Education and Psychology, University of Navarra, 31009, Pamplona, Spain., Romero-Garcia R; Department of Medical Physiology and Biophysics, Instituto de Biomedicina de Sevilla (IBiS), HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, 41013, Sevilla, Spain. rr480@cam.ac.uk.; Department of Psychiatry, University of Cambridge, Herchel Smith Bldg, Robinson Way, Cambridge, CB2 0SZ, UK. rr480@cam.ac.uk., Li C; Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; Department of Applied Mathematics and Theoretical Physics, The Centre for Mathematical Imaging in Healthcare, Cambridge, CB3 0WA, UK.; School of Medicine & School of Science and Engineering, University of Dundee, Dundee, DD1 4HN, UK., Morris RC; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Price SJ; Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Manly T; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, UK., Santarius T; Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Erez Y; Faculty of Engineering, Bar-Ilan University, 5290002, Ramat Gan, Israel.; The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel., Hart MG; St George's, University of London and St George's University Hospitals NHS Foundation Trust, Institute of Molecular and Clinical Sciences, Neurosciences Research Centre, Cranmer Terrace, London, SW17 0RE, UK., Suckling J; Department of Psychiatry, University of Cambridge, Herchel Smith Bldg, Robinson Way, Cambridge, CB2 0SZ, UK.; Cambridge and Peterborough NHS Foundation Trust, Cambridge, CB21 5EF, UK. |
| المصدر: | Scientific reports [Sci Rep] 2024 Mar 07; Vol. 14 (1), pp. 5646. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Brain Neoplasms*/diagnostic imaging , Brain Neoplasms*/surgery , Brain Neoplasms*/pathology , Cognitive Dysfunction*, Female ; Humans ; Cognition ; Diffusion Magnetic Resonance Imaging/methods ; Cerebral Cortex/pathology ; Brain/pathology |
| مستخلص: | Brain tumour microstructure is potentially predictive of changes following treatment to cognitive functions subserved by the functional networks in which they are embedded. To test this hypothesis, intra-tumoural microstructure was quantified from diffusion-weighted MRI to identify which tumour subregions (if any) had a greater impact on participants' cognitive recovery after surgical resection. Additionally, we studied the role of tumour microstructure in the functional interaction between the tumour and the rest of the brain. Sixteen patients (22-56 years, 7 females) with brain tumours located in or near speech-eloquent areas of the brain were included in the analyses. Two different approaches were adopted for tumour segmentation from a multishell diffusion MRI acquisition: the first used a two-dimensional four group partition of feature space, whilst the second used data-driven clustering with Gaussian mixture modelling. For each approach, we assessed the capability of tumour microstructure to predict participants' cognitive outcomes after surgery and the strength of association between the BOLD signal of individual tumour subregions and the global BOLD signal. With both methodologies, the volumes of partially overlapped subregions within the tumour significantly predicted cognitive decline in verbal skills after surgery. We also found that these particular subregions were among those that showed greater functional interaction with the unaffected cortex. Our results indicate that tumour microstructure measured by MRI multishell diffusion is associated with cognitive recovery after surgery. (© 2024. The Author(s).) |
| References: | Radiology. 2017 Jul;284(1):180-190. (PMID: 28240563) Acta Radiol. 2019 Mar;60(3):356-366. (PMID: 29860889) Neuroimage Clin. 2018 Apr 12;19:174-181. (PMID: 30023167) Neurosurgery. 2019 Oct 1;85(4):524-534. (PMID: 30239840) J Magn Reson Imaging. 2017 Jul;46(1):115-123. (PMID: 27678245) J Theor Biol. 2013 Apr 21;323:25-39. (PMID: 23376578) Stat Med. 2020 Dec 30;39(30):4704-4723. (PMID: 32964647) Clin Rehabil. 2003 Jul;17(4):386-93. (PMID: 12785247) Magn Reson Med. 2016 Oct;76(4):1149-57. (PMID: 26519663) Neuroimage. 2004;23 Suppl 1:S234-49. (PMID: 15501094) IEEE Trans Neural Netw. 2011 Feb;22(2):186-98. (PMID: 21095862) Cancers (Basel). 2021 Oct 06;13(19):. (PMID: 34638493) Magn Reson Imaging. 2009 Jan;27(1):120-30. (PMID: 18602785) J Biomed Phys Eng. 2018 Sep 01;8(3):251-260. (PMID: 30320029) J Neurosurg. 2021 Aug 06;136(2):358-368. (PMID: 34359041) Radiother Oncol. 2019 May;134:17-24. (PMID: 31005212) Neuroimage. 2012 Jul 16;61(4):1000-16. (PMID: 22484410) Contrast Media Mol Imaging. 2017 Oct 9;2017:6053879. (PMID: 29114178) J Neuroimaging. 2016 Sep;26(5):494-8. (PMID: 27214558) Neuroimage. 2005 Jul 1;26(3):839-51. (PMID: 15955494) Cortex. 2024 Jan 30;173:1-15. (PMID: 38354669) Neuroimage. 2018 Nov 15;182:232-250. (PMID: 29751058) World Neurosurg. 2020 May;137:e126-e137. (PMID: 31958585) Neuroimage. 2014 Apr 15;90:449-68. (PMID: 24389422) IEEE Trans Neural Netw Learn Syst. 2012 Aug;23(8):1177-93. (PMID: 24807516) Br J Radiol. 2006 Feb;79(938):101-9. (PMID: 16489190) |
| فهرسة مساهمة: | Keywords: Brain tumors; Diffusion MRI; Microstructure; Neurosurgery; Tumour microstructure |
| تواريخ الأحداث: | Date Created: 20240307 Date Completed: 20240311 Latest Revision: 20240311 |
| رمز التحديث: | 20240311 |
| مُعرف محوري في PubMed: | PMC10920778 |
| DOI: | 10.1038/s41598-024-55130-5 |
| PMID: | 38454017 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder كن أول من يترك تعليقا!