دورية أكاديمية
أعرض في EDS

Incidence of Nonkeratinocyte Skin Cancer After Breast Cancer Radiation Therapy.

التفاصيل البيبلوغرافية
العنوان: Incidence of Nonkeratinocyte Skin Cancer After Breast Cancer Radiation Therapy.
المؤلفون: Rezaei SJ; Department of Dermatology, Stanford University, Stanford, California.; Center for Digital Health, Stanford University, Stanford, California., Eid E; Department of Dermatology, Stanford University, Stanford, California., Tang JY; Department of Dermatology, Stanford University, Stanford, California., Kurian AW; Department of Medicine, Stanford University, Stanford, California.; Department of Epidemiology and Population Health, Stanford University, Stanford, California., Kwong BY; Department of Dermatology, Stanford University, Stanford, California., Linos E; Department of Dermatology, Stanford University, Stanford, California.; Center for Digital Health, Stanford University, Stanford, California.; Department of Epidemiology and Population Health, Stanford University, Stanford, California.
المصدر: JAMA network open [JAMA Netw Open] 2024 Mar 04; Vol. 7 (3), pp. e241632. Date of Electronic Publication: 2024 Mar 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Breast Neoplasms*/epidemiology , Breast Neoplasms*/radiotherapy , Melanoma*/epidemiology , Hemangiosarcoma* , Skin Neoplasms*/epidemiology , Skin Neoplasms*/etiology , Skin Neoplasms*/pathology, Humans ; Female ; Aged ; Cohort Studies ; Incidence
مستخلص: Importance: Previous studies have suggested that radiation therapy may contribute to an increased risk of subsequent nonkeratinocyte (ie, not squamous and basal cell) skin cancers.
Objective: To test the hypothesis that radiation therapy for breast cancer increases the risk of subsequent nonkeratinocyte skin cancers, particularly when these cancers are localized to the skin of the breast or trunk.
Design, Setting, and Participants: This population-based cohort study used longitudinal data from the Surveillance, Epidemiology, and End Results (SEER) Program for January 1, 2000, to December 31, 2019. The SEER database includes population-based cohort data from 17 registries. Patients with newly diagnosed breast cancer were identified and were evaluated for subsequent nonkeratinocyte skin cancer development. Data analysis was performed from January to August 2023.
Exposures: Radiation therapy, chemotherapy, or surgery for breast cancer.
Main Outcomes and Measures: The primary outcomes were standardized incidence ratios (SIRs) for subsequent nonkeratinocyte skin cancer development from 2000 to 2019 based on treatment type (radiation therapy, chemotherapy, or surgery), skin cancer site on the body, and skin cancer subtype.
Results: Among the 875 880 patients with newly diagnosed breast cancer included in this study, 99.3% were women, 51.6% were aged older than 60 years, and 50.3% received radiation therapy. A total of 11.2% patients identified as Hispanic, 10.1% identified as non-Hispanic Black, and 69.5% identified as non-Hispanic White. From 2000 to 2019, there were 3839 patients with nonkeratinocyte skin cancer, including melanoma (3419 [89.1%]), Merkel cell carcinoma (121 [3.2%]), hemangiosarcoma (104 [2.7%]), and 32 other nonkeratinocyte skin cancers (195 [5.1%]), documented to occur after breast cancer treatment. The risk of nonkeratinocyte skin cancer diagnosis after breast cancer treatment with radiation was 57% higher (SIR, 1.57 [95% CI, 1.45-1.7]) than that of the general population when considering the most relevant site: the skin of the breast or trunk. When risk at this site was stratified by skin cancer subtype, the SIRs for melanoma and hemangiosarcoma were both statistically significant at 1.37 (95% CI, 1.25-1.49) and 27.11 (95% CI, 21.6-33.61), respectively. Receipt of radiation therapy was associated with a greater risk of nonkeratinocyte skin cancer compared with chemotherapy and surgical interventions.
Conclusions and Relevance: In this study of patients with breast cancer, an increased risk of melanoma and hemangiosarcoma after breast cancer treatment with radiation therapy was observed. Although occurrences of nonkeratinocyte skin cancers are rare, physicians should be aware of this elevated risk to help inform follow-up care.
References: Lancet. 2011 Nov 12;378(9804):1707-16. (PMID: 22019144)
Am J Pathol. 2013 Oct;183(4):1084-1095. (PMID: 23895915)
JAMA Dermatol. 2021 Dec 01;157(12):1425-1436. (PMID: 34730781)
Surg Clin North Am. 2020 Feb;100(1):1-12. (PMID: 31753105)
J Am Acad Dermatol. 2021 Aug;85(2):388-395. (PMID: 33852922)
Front Oncol. 2022 Jul 27;12:892923. (PMID: 35965556)
Cancer. 2012 Jan 15;118(2):333-41. (PMID: 21717446)
Front Oncol. 2021 Aug 09;11:713328. (PMID: 34434899)
Breast Care (Basel). 2021 Aug;16(4):358-367. (PMID: 34602941)
Sci Rep. 2020 Jan 27;10(1):1220. (PMID: 31988348)
J Invest Dermatol. 2019 Sep;139(9):1898-1905.e2. (PMID: 30959042)
Pediatr Blood Cancer. 2013 Mar;60(3):461-6. (PMID: 22887858)
JAMA Intern Med. 2016 Oct 1;176(10):1435-1436. (PMID: 27459394)
Breast J. 2020 Mar;26(3):458-463. (PMID: 31448482)
JAMA. 2023 Apr 18;329(15):1324. (PMID: 37071093)
Radiother Oncol. 2020 Aug;149:212-218. (PMID: 32464163)
Nat Rev Dis Primers. 2019 Sep 23;5(1):66. (PMID: 31548545)
Am J Clin Oncol. 2002 Dec;25(6):597-8. (PMID: 12478007)
Radiat Oncol J. 2020 Jun;38(2):84-92. (PMID: 33012151)
J Am Acad Dermatol. 2022 Aug;87(2):255-268. (PMID: 35176397)
World J Surg. 2016 Apr;40(4):895-905. (PMID: 26711638)
Dermatol Clin. 2008 Jan;26(1):161-72, ix. (PMID: 18023776)
Br J Dermatol. 2021 Jun;184(6):1085-1093. (PMID: 33270213)
Int J Cancer. 2004 Sep 20;111(5):792-4. (PMID: 15252852)
CA Cancer J Clin. 2023 Jan;73(1):17-48. (PMID: 36633525)
Ann Plast Surg. 2019 Oct;83(4S Suppl 1):S59-S64. (PMID: 31513068)
CA Cancer J Clin. 2022 Sep;72(5):409-436. (PMID: 35736631)
J Cancer Res Clin Oncol. 2017 Sep;143(9):1701-1712. (PMID: 28429102)
Clin Breast Cancer. 2021 Feb;21(1):e96-e101. (PMID: 32855081)
تواريخ الأحداث: Date Created: 20240308 Date Completed: 20240311 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC10924238
DOI: 10.1001/jamanetworkopen.2024.1632
PMID: 38457179
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2024.1632