دورية أكاديمية
أعرض في EDS

Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine.

التفاصيل البيبلوغرافية
العنوان: Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine.
المؤلفون: Conti V; GSK Vaccines Institute for Global Health, Siena, Italy., Rossi O; GSK Vaccines Institute for Global Health, Siena, Italy., Clarkson KA; Department of Diarrheal Disease Research, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Horizon Therapeutics, Deerfield, IL, USA., Mancini F; GSK Vaccines Institute for Global Health, Siena, Italy., Nakakana UN; GSK Vaccines Institute for Global Health, Siena, Italy. usman.n.nakakana@gsk.com., Sarakinou E; GSK Vaccines Institute for Global Health, Siena, Italy., Callegaro A; GSK, Rixensart, Belgium., Ferruzzi P; GSK Vaccines Institute for Global Health, Siena, Italy., Acquaviva A; GSK Vaccines Institute for Global Health, Siena, Italy., Arora AK; GSK Vaccines Institute for Global Health, Siena, Italy., Marchetti E; GSK Vaccines Institute for Global Health, Siena, Italy., Necchi F; GSK Vaccines Institute for Global Health, Siena, Italy., Frenck RW Jr; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Martin LB; GSK Vaccines Institute for Global Health, Siena, Italy.; US Pharmacopeial Convention, Rockville, MD, USA., Kaminski RW; Department of Diarrheal Disease Research, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Latham BioPharm Group, Cambridge, MA, USA., Podda A; GSK Vaccines Institute for Global Health, Siena, Italy.; Independent Consultant, Siena, Italy., Micoli F; GSK Vaccines Institute for Global Health, Siena, Italy.
المصدر: NPJ vaccines [NPJ Vaccines] 2024 Mar 08; Vol. 9 (1), pp. 56. Date of Electronic Publication: 2024 Mar 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]-
مستخلص: Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection. We tested a S. sonnei Generalized Modules for Membrane Antigen (GMMA)-based vaccine (1790GAHB) in a phase 2b, placebo-controlled, randomized, controlled human infection model study (NCT03527173) enrolling healthy United States adults aged 18-50 years. We report analyses evaluating immune responses to vaccination, with the aim to identify correlates of risk for shigellosis among assessed immunomarkers. We found that 1790GAHB elicited S. sonnei lipopolysaccharide specific α4β7+ immunoglobulin (Ig) G and IgA secreting B cells which are likely homing to the gut, indicating the ability to induce a mucosal in addition to a systemic response, despite parenteral delivery. We were unable to establish or confirm threshold levels that predict vaccine efficacy facilitating the evaluation of vaccine candidates. However, serum anti-lipopolysaccharide IgG and bactericidal activity were identified as potential correlates of risk for shigellosis.
(© 2024. GlaxoSmithKline Biologicals S.A.)
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تواريخ الأحداث: Date Created: 20240308 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC10923941
DOI: 10.1038/s41541-024-00822-2
PMID: 38459072
قاعدة البيانات: MEDLINE
الوصف
تدمد:2059-0105
DOI:10.1038/s41541-024-00822-2