دورية أكاديمية
Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.
| العنوان: | Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure. |
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| المؤلفون: | Chidyagwai SG; Department of Biomedical Engineering, Duke University, 534 Research Drive, 27708, Durham, NC, USA., Kaplan MS; Department of Biomedical Engineering, Duke University, 534 Research Drive, 27708, Durham, NC, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Jensen CW; Department of Biomedical Engineering, Duke University, 534 Research Drive, 27708, Durham, NC, USA.; Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Chen JS; Department of Biomedical Engineering, Duke University, 534 Research Drive, 27708, Durham, NC, USA., Chamberlain RC; Division of Pediatric Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Hill KD; Division of Pediatric Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Barker PCA; Division of Pediatric Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Slesnick TC; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Randles A; Department of Biomedical Engineering, Duke University, 534 Research Drive, 27708, Durham, NC, USA. amanda.randles@duke.edu. |
| المصدر: | Cardiovascular engineering and technology [Cardiovasc Eng Technol] 2024 Aug; Vol. 15 (4), pp. 431-442. Date of Electronic Publication: 2024 Mar 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101531846 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-4098 (Electronic) Linking ISSN: 1869408X NLM ISO Abbreviation: Cardiovasc Eng Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Springer |
| مواضيع طبية MeSH: | Pulmonary Artery*/physiopathology , Pulmonary Artery*/surgery , Pulmonary Artery*/diagnostic imaging , Hypoplastic Left Heart Syndrome*/surgery , Hypoplastic Left Heart Syndrome*/physiopathology , Hypoplastic Left Heart Syndrome*/diagnostic imaging , Norwood Procedures* , Models, Cardiovascular* , Stress, Mechanical* , Hemodynamics*, Humans ; Pulmonary Circulation ; Patient-Specific Modeling ; Cineangiography ; Blood Flow Velocity ; Infant, Newborn ; Treatment Outcome |
| مستخلص: | Purposr: This study created 3D CFD models of the Norwood procedure for hypoplastic left heart syndrome (HLHS) using standard angiography and echocardiogram data to investigate the impact of shunt characteristics on pulmonary artery (PA) hemodynamics. Leveraging routine clinical data offers advantages such as availability and cost-effectiveness without subjecting patients to additional invasive procedures. Methods: Patient-specific geometries of the intrathoracic arteries of two Norwood patients were generated from biplane cineangiograms. "Virtual surgery" was then performed to simulate the hemodynamics of alternative PA shunt configurations, including shunt type (modified Blalock-Thomas-Taussig shunt (mBTTS) vs. right ventricle-to-pulmonary artery shunt (RVPAS)), shunt diameter, and pulmonary artery anastomosis angle. Left-right pulmonary flow differential, Q Results: There was strong agreement between clinically measured data and CFD model output throughout the patient-specific models. Geometries with a RVPAS tended toward more balanced left-right pulmonary flow, lower Q Conclusion: Excellent correlation between clinically measured and CFD model data shows that 3D CFD models of HLHS Norwood can be developed using standard angiography and echocardiographic data. The CFD analysis also revealed consistent changes in PA TAWSS, flow differential, and OSI as a function of shunt characteristics. (© 2024. The Author(s) under exclusive licence to Biomedical Engineering Society.) |
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| معلومات مُعتمدة: | DP5OD019876 United States NH NIH HHS; DP1AG082343 United States NH NIH HHS; DP5OD019876 United States NH NIH HHS; DP1AG082343 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: Computational fluid dynamics; Coronary perfusion; Hypoplastic left heart syndrome; Norwood procedure |
| تواريخ الأحداث: | Date Created: 20240308 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1007/s13239-024-00724-3 |
| PMID: | 38459240 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1869-4098 |
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| DOI: | 10.1007/s13239-024-00724-3 |