دورية أكاديمية
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5-fluorouracil in rats.
| العنوان: | Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5-fluorouracil in rats. |
|---|---|
| المؤلفون: | Karim B; Student Research Committee, Babol University of Medical Sciences, Babol, Iran., Arabameri M; Department of Pharmacology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran., Alimoradi F; Department of Pharmacology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran., Mansoori R; Pharmaceutical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Moghadamnia AA; Pharmaceutical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Kazemi S; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Hosseini SM; Department of Veterinary Pathology, Babol-Branch, Islamic Azad University, Babol, Iran. |
| المصدر: | Drug development research [Drug Dev Res] 2024 Apr; Vol. 85 (2), pp. e22171. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York : Alan R. Liss, c1981- |
| مواضيع طبية MeSH: | Cardiotoxicity*/drug therapy , Cardiotoxicity*/etiology , Cardiotoxicity*/prevention & control , Antioxidants*/pharmacology , Antioxidants*/metabolism , Benzoquinones*, Rats ; Male ; Animals ; Rats, Wistar ; Fluorouracil/toxicity ; Oxidative Stress |
| مستخلص: | 5-Fluorouracil (5-FU), which is one of the most widely used chemotherapy drugs, has various side effects on the heart. Thymoquinone (TMQ), the main bioactive component of Nigella sativa, has antioxidant and protective effects against toxicity. In this study, we investigated the protective effect of thymoquinone against cardiotoxicity caused by 5-FU in vitro and in vivo models. H9C2 cells were exposed to 5-FU and TMQ, and cell viability was evaluated in their presence. Also, 25 male Wistar rats were divided into five control groups, 5-FU, 2.5, and 5 mg TMQ in nanoemulsion form (NTMQ) + 5-FU and 5 mg NTMQ. Cardiotoxicity was assessed through electrocardiography, cardiac enzymes, oxidative stress markers, and histopathology. 5-FU induced cytotoxicity in H9c2 cells, which improved dose-dependently with NTMQ cotreatment. 5-FU caused body weight loss, ECG changes (increased ST segment, prolonged QRS, and QTc), increased cardiac enzymes (aspartate aminotransferase [AST], creatine kinase-myocardial band [CK-MB], and lactate dehydrogenase [LDH]), oxidative stress (increased malondialdehyde, myeloperoxidase, nitric acid; decreased glutathione peroxidase enzyme activity), and histological damage such as necrosis, hyperemia, and tissue hyalinization in rats. NTMQ ameliorated these 5-FU-induced effects. Higher NTMQ dose showed greater protective effects. Thus, the results of our study indicate that NTMQ protects against 5-FU cardiotoxicity likely through antioxidant mechanisms. TMQ warrants further research as an adjuvant to alleviate 5-FU chemotherapy side effects. (© 2024 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: 5-Fluorouracil; ECG; cardiotoxicity; oxidative stress; thymoquinone |
| المشرفين على المادة: | 0 (Antioxidants) O60IE26NUF (thymoquinone) U3P01618RT (Fluorouracil) 0 (Benzoquinones) |
| تواريخ الأحداث: | Date Created: 20240309 Date Completed: 20240311 Latest Revision: 20240311 |
| رمز التحديث: | 20240311 |
| DOI: | 10.1002/ddr.22171 |
| PMID: | 38459752 |
| قاعدة البيانات: | MEDLINE |
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