دورية أكاديمية
أعرض في EDS

Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study.
المؤلفون: Chiu CD; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan., Chiu PF; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan., Wu CY; Department of Neurosurgery, China Medical University Hsinchu Hospital, Hsinchu, Taiwan.; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan., Yip HT; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan., Chiu YP; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Ji HR; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Hsu KC; Artificial Intelligence Center for Medical Diagnosis, China Medical University, Taichung, Taiwan.; Department 0f Neurology, China Medical University Hospital, Taichung, Taiwan., Tsai FJ; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Division of Medical Genetics, China Medical University Children's Hospital, Taichung, Taiwan.; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan., Chang RC; Department of Electrical Engineering, National Chung Hsing University, Taichung, Taiwan.
المصدر: International journal of medical sciences [Int J Med Sci] 2024 Jan 27; Vol. 21 (4), pp. 656-663. Date of Electronic Publication: 2024 Jan 27 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Australia] : Ivyspring International Publisher, c2004-
مواضيع طبية MeSH: Hydrocephalus, Normal Pressure*/epidemiology , Hydrocephalus, Normal Pressure*/surgery, Humans ; Aged ; Retrospective Studies ; Lipopolysaccharides ; Ventriculoperitoneal Shunt/adverse effects ; Ventriculoperitoneal Shunt/methods ; Vascular Surgical Procedures ; Treatment Outcome
مستخلص: Purpose: With advances in medical technology, the average lifespan has increased, leading to a growing significance of idiopathic normal pressure hydrocephalus (iNPH), particularly in the elderly population. Most patients with iNPH have been treated either with ventriculo-peritoneal shunts (VPS) or conservative measures. However, lumbo-peritoneal shunts (LPS) have emerged as an alternative treatment option for iNPH in recent decades, extensive research still lacks comparing outcomes with LPS to those with VPS or non-surgical treatment. The aim of the resent study is to disclose the long-term therapeutic outcomes of LPS, VPS, and non-shunting in patients with iNPH. Methods: We used the National Health Insurance Research Database in Taiwan to assess the long-term outcomes of these treatment options. We enrolled 5,537 iNPH patients who received shunting surgery, of which 5,254 were VPS and 283 were LPS. To compare the difference between each group, matching was conducted by propensity score matching using a 1:1 ratio based on LPS patients. Primary outcomes included death and major adverse cardiovascular events (MACEs) Results: Our findings show that VPS resulted in significantly more MACEs than non-surgical treatment (Odds ratio: 1.83, 95% confidence interval: 1.16-2.90). In addition, both VPS and LPS groups had significantly lower overall mortality rates than non-shunting group. Moreover, LPS had lower overall mortality but similar MACEs rates to VPS. Conclusions: Based on these findings, we propose that the LPS is preferable to the VPS, and surgical treatment should be considered the primary choice over conservative treatment unless contraindications are present.
Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
(© The author(s).)
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فهرسة مساهمة: Keywords: idiopathic normal pressure hydrocephalus; lumbo-peritoneal shunt; major adverse cardiovascular events; ventriculo-peritoneal shunt
المشرفين على المادة: 0 (Lipopolysaccharides)
تواريخ الأحداث: Date Created: 20240311 Date Completed: 20240312 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC10920851
DOI: 10.7150/ijms.92032
PMID: 38464824
قاعدة البيانات: MEDLINE
الوصف
تدمد:1449-1907
DOI:10.7150/ijms.92032