دورية أكاديمية
Volatilomic profiles of gastric juice in gastric cancer patients.
| العنوان: | Volatilomic profiles of gastric juice in gastric cancer patients. |
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| المؤلفون: | Mezmale L; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.; Riga East University Hospital, Riga, Latvia.; Riga Stradins University, LV-1007, Riga, Latvia., Ślefarska-Wolak D; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria.; Institute of Chemistry, Jan Kochanowski University of Kielce, Kielce, Poland., Bhandari MP; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia., Ager C; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria., Veliks V; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia., Patsko V; National Cancer Institute of Ukraine, Kyiv, Ukraine., Lukashenko A; National Cancer Institute of Ukraine, Kyiv, Ukraine., Dias-Neto E; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Nunes DN; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Bartelli TF; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Pelosof AG; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Sztokfisz CZ; Medical Genomics group and Endoscopy Center, A.C.Camargo Cancer Center, São Paulo, Brazil., Murillo R; University Hospital San Ignacio, Bogotá, Colombia., Królicka A; Department of Building Materials Technology, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, Krakow, Poland., Mayhew CA; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria., Leja M; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.; Riga East University Hospital, Riga, Latvia.; Digestive Diseases Centre GASTRO, Riga, Latvia., Haick H; Department of Chemical Engineering and Russel Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel., Mochalski P; Institute for Breath Research, Universität Innsbruck, Innsbruck and Dornbirn, Austria.; Institute of Chemistry, Jan Kochanowski University of Kielce, Kielce, Poland. |
| المصدر: | Journal of breath research [J Breath Res] 2024 Mar 21; Vol. 18 (2). Date of Electronic Publication: 2024 Mar 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Pub Country of Publication: England NLM ID: 101463871 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-7163 (Electronic) Linking ISSN: 17527155 NLM ISO Abbreviation: J Breath Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol, UK : IOP Pub. |
| مواضيع طبية MeSH: | Stomach Neoplasms* , Volatile Organic Compounds*/analysis, Humans ; Gas Chromatography-Mass Spectrometry/methods ; Breath Tests/methods ; Biomarkers/analysis ; Solid Phase Microextraction/methods ; Gastric Juice/metabolism |
| مستخلص: | Volatilomics is a powerful tool capable of providing novel biomarkers for the diagnosis of gastric cancer. The main objective of this study was to characterize the volatilomic signatures of gastric juice in order to identify potential alterations induced by gastric cancer. Gas chromatography with mass spectrometric detection, coupled with headspace solid phase microextraction as the pre-concentration technique, was used to identify volatile organic compounds (VOCs) released by gastric juice samples collected from 78 gastric cancer patients and two cohorts of controls (80 and 96 subjects) from four different locations (Latvia, Ukraine, Brazil, and Colombia). 1440 distinct compounds were identified in samples obtained from patients and 1422 in samples provided by controls. However, only 6% of the VOCs exhibited an incidence higher than 20%. Amongst the volatiles emitted, 18 showed differences in their headspace concentrations above gastric juice of cancer patients and controls. Ten of these (1-propanol, 2,3-butanedione, 2-pentanone, benzeneacetaldehyde, 3-methylbutanal, butylated hydroxytoluene, 2-pentyl-furan, 2-ethylhexanal, 2-methylpropanal and phenol) appeared at significantly higher levels in the headspace of the gastric juice samples obtained from patients; whereas, eight species showed lower abundance in patients than found in controls. Given that the difference in the volatilomic signatures can be explained by cancer-related changes in the activity of certain enzymes or pathways, the former set can be considered potential biomarkers for gastric cancer, which may assist in developing non-invasive breath tests for the diagnosis of this disease. Further studies are required to elucidate further the mechanisms that underlie the changes in the volatilomic profile as a result of gastric cancer. (© 2024 IOP Publishing Ltd.) |
| فهرسة مساهمة: | Keywords: GC-MS; biomarker; gastric cancer; gastric juice; volatile organic compound; volatilome |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Volatile Organic Compounds) |
| تواريخ الأحداث: | Date Created: 20240311 Date Completed: 20240322 Latest Revision: 20240605 |
| رمز التحديث: | 20240605 |
| DOI: | 10.1088/1752-7163/ad324f |
| PMID: | 38467063 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1752-7163 |
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| DOI: | 10.1088/1752-7163/ad324f |