دورية أكاديمية
أعرض في EDS

Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity.

التفاصيل البيبلوغرافية
العنوان: Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity.
المؤلفون: Cefalo CMA; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy., Riccio A; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy., Fiorentino TV; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Succurro E; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Mannino GC; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Perticone M; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Sciacqua A; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Andreozzi F; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy., Sesti G; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
المصدر: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 May; Vol. 32 (5), pp. 888-899. Date of Electronic Publication: 2024 Mar 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: In Process; MEDLINE
أسماء مطبوعة: Publication: 2013- : Malden, MA : John Wiley & Sons
Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006-
مستخلص: Objective: Reduced myocardial mechano-energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with "metabolically healthy overweight" (MHOW) and "metabolically healthy obesity" (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components of metabolic syndrome, exhibit impaired MEE compared with their unhealthy counterparts.
Methods: Myocardial MEE per gram of left ventricular mass (MEEi) was assessed by echocardiography in 2190 nondiabetic individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study who were divided, according to BMI and metabolic status, into groups of individuals with metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), MHOW, metabolically unhealthy overweight (MUOW), MHO, and metabolically unhealthy obesity (MUO).
Results: After adjusting for age and sex, no differences in myocardial MEEi were observed among individuals with MHNW, MHOW, and MHO (p = 0.56). Myocardial MEEi was comparable among individuals with MUNW, MUOW, and MUO (p = 0.21). Individuals with MHNW, MHOW, and MHO displayed significantly higher myocardial MEEi compared with their unhealthy counterparts.
Conclusions: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.
(© 2024 The Obesity Society.)
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معلومات مُعتمدة: RM1201728887461F Sapienza University of Rome; European Foundation for the Study of Diabetes EFSD/Lilly Young Investigator Research Award; Italian Internal Medicine Society Mario Condorelli Award; 2020N5WK98_005 Italian Ministry for University and Research
تواريخ الأحداث: Date Created: 20240311 Latest Revision: 20240806
رمز التحديث: 20240807
DOI: 10.1002/oby.24006
PMID: 38467153
قاعدة البيانات: MEDLINE
الوصف
تدمد:1930-739X
DOI:10.1002/oby.24006