دورية أكاديمية
أعرض في EDS

Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease.

التفاصيل البيبلوغرافية
العنوان: Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease.
المؤلفون: Bhosle A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Bae S; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Zhang Y; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Chun E; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Avila-Pacheco J; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Geistlinger L; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.; Center for Computational Biomedicine, Harvard Medical School, Boston, MA, USA., Pishchany G; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Glickman JN; Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Michaud M; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Waldron L; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA., Clish CB; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xavier RJ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA., Vlamakis H; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Franzosa EA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Garrett WS; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Huttenhower C; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. chuttenh@hsph.harvard.edu.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu.
المصدر: Molecular systems biology [Mol Syst Biol] 2024 Apr; Vol. 20 (4), pp. 338-361. Date of Electronic Publication: 2024 Mar 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: EMBO Press Country of Publication: England NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : Heidelberg : EMBO Press
Original Publication: London : Nature Pub. Group, c2005-
مواضيع طبية MeSH: Inflammatory Bowel Diseases*/drug therapy , Inflammatory Bowel Diseases*/metabolism , Colitis*, Humans ; Animals ; Mice ; Metabolome ; Bile Acids and Salts
مستخلص: Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases (IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is thus necessary for diagnosis and management. Here, we systematically analyzed the chemical, ecological, and epidemiological properties of ~82k metabolic features in 546 Integrative Human Microbiome Project (iHMP/HMP2) metabolomes, using a newly developed methodology for bioactive compound prioritization from microbial communities. This suggested >1000 metabolic features as potentially bioactive in IBD and associated ~43% of prevalent, unannotated features with at least one well-characterized metabolite, thereby providing initial information for further characterization of a significant portion of the fecal metabolome. Prioritized features included known IBD-linked chemical families such as bile acids and short-chain fatty acids, and less-explored bilirubin, polyamine, and vitamin derivatives, and other microbial products. One of these, nicotinamide riboside, reduced colitis scores in DSS-treated mice. The method, MACARRoN, is generalizable with the potential to improve microbial community characterization and provide therapeutic candidates.
(© 2024. The Author(s).)
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معلومات مُعتمدة: P30 DK040561 United States DK NIDDK NIH HHS; R01 CA230551 United States CA NCI NIH HHS; R24 DK110499 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Bioactive Compound Prioritization; Computational Method; Inflammatory Bowel Disease; Metabolomics; Microbiome
المشرفين على المادة: 0 (Bile Acids and Salts)
تواريخ الأحداث: Date Created: 20240312 Date Completed: 20240404 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC10987656
DOI: 10.1038/s44320-024-00027-8
PMID: 38467837
قاعدة البيانات: MEDLINE
الوصف
تدمد:1744-4292
DOI:10.1038/s44320-024-00027-8