دورية أكاديمية
Anticandida and antibiofilm activities of extract from Schinopsis brasiliensis Engl. against Candida spp.
| العنوان: | Anticandida and antibiofilm activities of extract from Schinopsis brasiliensis Engl. against Candida spp. |
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| المؤلفون: | Jovito VC; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil., Lima JM; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil., Rangel ML; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil., Gondim BLC; Universidade Estadual da Paraíba - UEPB, Departament of Pharmaceutical Sciences, Campina Grande, PB, Brazil., Nogueira PL; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil., Medeiros ACD; Universidade Estadual da Paraíba - UEPB, Departament of Pharmaceutical Sciences, Campina Grande, PB, Brazil., Sobral MV; Universidade Federal da Paraíba - UFPB, Departament of Pharmaceutical Sciences, João Pessoa, PB, Brazil., Castro RD; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil., Castellano LRC; Universidade Federal da Paraíba - UFPB, Graduate Program in Dentistry, Departament of Clinical and Social Dentistry, João Pessoa-PB, Brazil. |
| المصدر: | Brazilian oral research [Braz Oral Res] 2024 Mar 11; Vol. 38, pp. e016. Date of Electronic Publication: 2024 Mar 11 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Pesquisa Odontológica Country of Publication: Brazil NLM ID: 101307187 Publication Model: eCollection Cited Medium: Internet ISSN: 1807-3107 (Electronic) Linking ISSN: 18068324 NLM ISO Abbreviation: Braz Oral Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, SP : Sociedade Brasileira de Pesquisa Odontológica |
| مواضيع طبية MeSH: | Candida* , Anacardiaceae*, Humans ; Antifungal Agents ; Nystatin ; Candida albicans ; Biofilms ; Gallic Acid ; Plant Extracts |
| مستخلص: | The pathogenic nature of infections caused by Candida spp. underscores the necessity for novel therapeutic agents. Extracts of Schinopsis brasilienses Engl are \ a promising source of agents with antifungal effects. This study aimed to assess the antifungal potential of the leaf extract of S. brasilienses. The antifungal activity was evaluated by determining the minimum inhibitory concentrations and fungicide concentrations (MIC and MFC). The antibiofilm potential was assessed by counting colony-forming units/mL. The study examined the inhibition kinetics of fungal growth and potential synergism between gallic acid or the extract and nystatin using the Checkerboard method. Cytotoxicity was evaluated through the MTT assay. The extract exhibited antifungal effect against all tested strains, with MIC and MFC ranging from 31.25-250 μg/mL. Gallic acid, the main isolated compound, displayed a MIC of 2000 μg/mL. The extract of S. brasilienses at 31.25 μg/mL inhibited the formation of biofilm by C. albicans and significantly reduced the mass of mature biofilm after 24 and 48 h (p < 0. 05). At a concentration of 125 μg/mL, the extract demonstrated significant inhibition of fungal growth after 6 hours. The combination of gallic acid or extract with nystatin did not exhibit synergistic or antagonistic effect. Furthermore, the extract did not induce cytotoxicity to a human cell line. The extract of S. brasiliensis demonstrates antifungal activity against Candida, generally exhibiting fungicidal action and capacity to inhibit biofilm formation as well as reduce mature biofilms. Additionally, the extract showed low cytotoxicity to human cells. |
| المشرفين على المادة: | 0 (Antifungal Agents) 1400-61-9 (Nystatin) 632XD903SP (Gallic Acid) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240314 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| DOI: | 10.1590/1807-3107bor-2024.vol38.0016 |
| PMID: | 38477802 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1807-3107 |
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| DOI: | 10.1590/1807-3107bor-2024.vol38.0016 |