دورية أكاديمية
Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area.
| العنوان: | Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area. |
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| المؤلفون: | Dawudi Y; Neurology Department, Centre Hospitalier de Saint-Denis, 2 Rue du Dr Delafontaine, 93200, Saint-Denis, France. yachar.dawudi@aphp.fr.; Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136, Sorbonne Université INSERM, Paris, France. yachar.dawudi@aphp.fr., Azoyan L; Neurology Department, Centre Hospitalier de Saint-Denis, 2 Rue du Dr Delafontaine, 93200, Saint-Denis, France.; Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136, Sorbonne Université INSERM, Paris, France., Broucker TDE; Neurology Department, Centre Hospitalier de Saint-Denis, 2 Rue du Dr Delafontaine, 93200, Saint-Denis, France., Gendre T; Neurology Department, Hôpital Henri-Mondor, 1 Rue Gustave Eiffel, 94000, Créteil, France., Miloudi A; Neurology Department, Centre Hospitalier Intercommunal Robert Ballanger, Bd Robert Ballanger, 93600, Aulnay-Sous-Bois, France., Echaniz-Laguna A; Neurology Department, Hôpital Bicêtre, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France., Mazoyer J; Neurology Department, Hôpital Avicenne, 125 Route de Stalingrad, 93009, Bobigny, France., Zanin A; Clinical Physiology Department, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75010, Paris, France., Kubis N; Clinical Physiology Department, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75010, Paris, France., Dubessy AL; Neurology Department, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, 75012, Paris, France., Gorza L; Neurology Department, Hôpital Foch, 40 Rue Worth, 92150, Suresnes, France., Ben Nasr H; Neurology Department, Centre Hospitalier Sud Francilien, 40 Avenue Serge Dassault, 91100, Corbeil-Essonnes, France., Caré W; Department of Internal Medicine, Bégin Military Teaching Hospital, Saint-Mandé, France.; Paris Poison Control Center, Toxicology Federation (FeTox), Hôpital Fernand Widal, AP-HP, Paris, France., d'Izarny-Gargas T; Paris Cardiovascular Research Center, INSERM U970, Paris, France., Formoso A; Neurology Department, Hôpital de La Pitié Salpêtrière, 47-83 Bd de L'Hôpital, 75013, Paris, France., Vilcu AM; Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136, Sorbonne Université INSERM, Paris, France., Bonnan M; Neurology Department, Centre Hospitalier de Saint-Denis, 2 Rue du Dr Delafontaine, 93200, Saint-Denis, France. |
| المصدر: | Journal of neurology [J Neurol] 2024 Jun; Vol. 271 (6), pp. 3340-3346. Date of Electronic Publication: 2024 Mar 13. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York, Springer-Verlag |
| مواضيع طبية MeSH: | Nitrous Oxide*/adverse effects , Substance-Related Disorders*/epidemiology, Humans ; Male ; Female ; Adult ; Retrospective Studies ; Paris/epidemiology ; Young Adult ; Middle Aged ; Incidence ; Nervous System Diseases/epidemiology ; Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/epidemiology ; Peripheral Nervous System Diseases/chemically induced ; Spinal Cord Diseases/epidemiology ; Spinal Cord Diseases/chemically induced ; Aged ; Adolescent ; Recreational Drug Use/statistics & numerical data |
| مستخلص: | Background: Recreational nitrous oxide (N Methods: We performed a retrospective multicentric cohort study of all adult patients with severe NI-NDs in the neurology and general internal medicine departments of the Greater Paris area from 2018 to 2021. The incidence was compared with that of non-NI-myelitis and Guillain-Barré syndrome (GBS) using a sample of 91,000 hospitalized patients sourced from health insurance data. Results: Among 181 patients, 25% had myelopathy, 37% had peripheral neuropathy and 38% had mixed disease. Most were aged between 20 and 25 years, lived in socially disadvantaged urban areas, and exhibited high rates of unemployment (37%). The incidence of NI-NDs increased during 2020 and reached a peak mid-2021. The 2021 incidence in 20-25-year-olds was 6.15 [4.72; 8.24] per 100,000 persons for NI-myelopathy and 7.48 [5.59; 9.37] for NI-peripheral neuropathy. This was significantly higher than for non-NI-myelitis (0.35 [0.02; 2.00]) and GBS (2.47 [0.64; 4.30]). The incidence of NI-NDs was two to three times higher in the most socially disadvantaged areas. Conclusion: The recent increase in recreational N (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Epidemiology; Myelopathy; Nitrous oxyde abuse; Peripheral neuropathy |
| المشرفين على المادة: | K50XQU1029 (Nitrous Oxide) |
| تواريخ الأحداث: | Date Created: 20240313 Date Completed: 20240529 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11136741 |
| DOI: | 10.1007/s00415-024-12264-w |
| PMID: | 38478030 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-1459 |
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| DOI: | 10.1007/s00415-024-12264-w |