Role of serum calprotectin in identifying familial Mediterranean fever attacks.

التفاصيل البيبلوغرافية
العنوان:	Role of serum calprotectin in identifying familial Mediterranean fever attacks.
المؤلفون:	Polat MG; Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Turkey. drgokcenpolat@gmail.com., Omma A; Department of Internal Medicine, Division of Rheumatology, Ankara Bilkent City Hospital, Ankara, Turkey., Gokcen N; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Kilinckaya MF; Department of Clinical Biochemistry, Ankara Bilkent City Hospital, Ankara, Turkey., Ozkan Karaahmetoglu S; Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Turkey.
المصدر:	Irish journal of medical science [Ir J Med Sci] 2024 Aug; Vol. 193 (4), pp. 1901-1909. Date of Electronic Publication: 2024 Mar 13.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Royal Academy of Medicine of Ireland Country of Publication: Ireland NLM ID: 7806864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-4362 (Electronic) Linking ISSN: 00211265 NLM ISO Abbreviation: Ir J Med Sci Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Dublin : Royal Academy of Medicine of Ireland
مواضيع طبية MeSH:	Familial Mediterranean Fever/blood , Leukocyte L1 Antigen Complex/blood , Blood Sedimentation* , C-Reactive Protein*/analysis, Humans ; Female ; Male ; Adult ; ROC Curve ; Middle Aged ; Biomarkers/blood ; Arthritis, Rheumatoid/blood ; Case-Control Studies ; Young Adult
مستخلص:	Background/aim: The aim of the study was to evaluate serum calprotectin (CLP) levels in familial Mediterranean fever (FMF) patients and to investigate the utility of CLP in distinguishing patients with attack from patients without attack. Material and Method: FMF patients, rheumatoid arthritis (RA) patients, and healthy controls were included. Serum calprotectin levels were quantified utilizing the enzyme-linked immunosorbent assay (ELISA) method. Receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of serum CLP level to differentiate FMF patients with attack from those without. Logistic regression analysis was performed to identify predictors. Results: Significant differences were observed among the three groups concerning white blood cell (WBC), neutrophil, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum CLP levels (p = 0.003, p = 0.004, p < 0.001, p < 0.001, and p = 0.002, respectively). Higher ESR, CRP, and serum CLP levels were observed in FMF patients with attacks than those without (all, p < 0.001). Serum CLP was significantly higher in RA patients than in FMF patients in remission (p < 0.001). ROC analysis identified a threshold CLP concentration in FMF with an attack to be 47.1 pg/mL (83.3% sensitivity, 60.6% specificity, AUC = 0.74, 95% CI = 0.63-0.85, p < 0.001). In univariate logistic regression analysis, CLP (β = 1.045, 95% CI = 1.017-1.073, p = 0.001) was predictive of FMF patients experiencing an attack. Conclusion: Serum CLP proves to be as productive as ESR in illustrating inflammation and demonstrating the existence of attacks in FMF patients. (© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
References:	Gucenmez OA, Kume T, Makay B et al (2018) Role of fecal calprotectin in the assessment of intestinal inflammation in children with familial Mediterranean fever. Int J Rheum Dis 21:1844–1848. https://doi.org/10.1111/1756-185X.13396. (PMID: 10.1111/1756-185X.1339630345692) Yalçınkaya F, Özen S, Özçakar Z et al (2009) A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology 48(4):395–398. (PMID: 10.1093/rheumatology/ken50919193696) Korkmaz C, Özdogan H, Kasapçopur Ö et al (2002) Acute phase response in familial Mediterranean fever. Ann Rheum Dis 61(1):79–81. (PMID: 10.1136/ard.61.1.79117797671753891) Lachmann H, Şengül B, Yavuzşen TU et al (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology 45(6):746–750. https://doi.org/10.1093/rheumatology/kei279. (PMID: 10.1093/rheumatology/kei27916403826) Shohat M, Halpern GJ (2011) Familial Mediterranean fever a review. Genet Med 13(6):487–498. (PMID: 10.1097/GIM.0b013e318206045621358337) Chae JJ, Aksentijevich I, Kastner DL (2009) Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol 146:467–478. https://doi.org/10.1111/J.1365-2141.2009.07733.X. (PMID: 10.1111/J.1365-2141.2009.07733.X194669782759843) Gumucio DL, Diaz A, Schaner P et al (2002) Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol 20(4; SUPP/26):45–53. Chae J, Wood G, Richard K et al (2008) The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment. The Journal of the American Society of Hematology 112(5):1794–1803. Nishikawa Y, Kajiura Y, Lew JH et al (2017) Calprotectin induces IL-6 and MCP-1 production via toll-like receptor 4 signaling in human gingival fibroblasts. J Cell Physiol 232:1862–1871. https://doi.org/10.1002/jcp.25724. (PMID: 10.1002/jcp.2572427925202) Garcia V, Perera Y, Biomolecules WC et al (2022) A structural perspective on calprotectin as a ligand of receptors mediating inflammation and potential drug target. Biomolecules 12(4):519. (PMID: 10.3390/biom12040519354541089026754) Kopeć-Mędrek M, Widuchowska M, Kucharz EJ (2016) Calprotectin in rheumatic diseases: a review. Reumatologia 54(6):306. https://doi.org/10.5114/reum.2016.64907. (PMID: 10.5114/reum.2016.64907281157815241367) Kılıçaslan E, Düzenli T, Çelik S et al (2022) Assessment of serum resistin and plasma calprotectin levels as biomarkers of ınflammation in patients with familial Mediterranean fever disease. Mediterr J Rheumatol 33:322. https://doi.org/10.31138/MJR.33.3.322. (PMID: 10.31138/MJR.33.3.322365314169727476) Asan G, Derin ME, Doğan HO et al (2020) Can calprotectin show subclinical inflammation in familial Mediterranean fever patients. J Korean Med Sci 35(10):e63. https://doi.org/10.3346/jkms.2020.35.e63. (PMID: 10.3346/jkms.2020.35.e63321740627073319) Dzhndoian Z (2012) Serum levels of myeloıd-related proteın Mrp 8/14 (calprotectın) ın Armenıan patıents wıth famılıal Medıterranean fever (FMF). Ter Arkh 84(6):45–48. (PMID: 22997918) Holzinger D, Roth J (2016) Alarming consequences–autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1. Rheumatology J 28(5):550–559. https://doi.org/10.1097/BOR.0000000000000314. (PMID: 10.1097/BOR.0000000000000314) Jorch SK, McNally A, Berger P et al (2023) Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever. J Allergy Clin Immunol 152:230–243. https://doi.org/10.1016/J.JACI.2023.01.03. (PMID: 10.1016/J.JACI.2023.01.0336822481) Neogi T, Aletaha D, Silman AJ et al (2010) The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report. Arthritis Rheum 62:2582–2591. https://doi.org/10.1002/ART.27580. (PMID: 10.1002/ART.27580208725963077961) Kalla R, Kennedy NA, Ventham NT et al (2016) Serum calprotectin: a novel diagnostic and prognostic marker in inflammatory bowel diseases. Am J Gastroenterol Suppl. 111(12):1796–1805. https://doi.org/10.1038/ajg.2016.342. (PMID: 10.1038/ajg.2016.342) Unal I (2017) Defining an optimal cut-point value in ROC analysis: an alternative approach. Comput Math Methods Med 2017:3762651. https://doi.org/10.1155/2017/3762651. (PMID: 10.1155/2017/3762651286428045470053) Fangyu L, Hua H (2018) Assessing the accuracy of diagnostic tests. Shanghai Arch Psychiatry 30(3):207. Jung S, Park Y, Ha Y et al (2006) Serum calprotectin as a marker for disease activity and severity in adult-onset Still’s disease. J Rheumatol 8(3):1–12. Arias MG, Pascual-Salcedo D, Ueberschlag M-E et al (2013) Calprotectin in rheumatoid arthritis: association with disease activity in a cross-sectional and a longitudinal cohort. Mol Diagn Ther 17:49–56. https://doi.org/10.1007/s40291-013-0016-9. (PMID: 10.1007/s40291-013-0016-9) Oktayoglu P, Bozkurt M, Mete N et al (2014) Elevated serum levels of calprotectin (myeloid-related protein 8/14) in patients with ankylosing spondylitis and its association with disease activity and quality of life. J Investig Med 62:880–884. https://doi.org/10.1097/JIM.0000000000000095. (PMID: 10.1097/JIM.000000000000009524922195) Inciarte-Mundo J, Ramirez J, Hernández MV et al (2016) Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity. Arthritis Res Ther 8(1):160. https://doi.org/10.1186/S13075-016-1032-Z. (PMID: 10.1186/S13075-016-1032-Z) Nordal HH, Brun JG, Halse AK et al (2014) Calprotectin (S100A8/A9), S100A12, and EDTA-resistant S100A12 complexes (ERAC) in primary Sjögren’s syndrome Scandinavian. J Rheumatol 43(1):76–78. https://doi.org/10.3109/03009742.2013.848930. (PMID: 10.3109/03009742.2013.848930) Frosch M, Ahlmann M, Vogl T et al (2009) The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1β form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 60:883–891. https://doi.org/10.1002/ART.24349. (PMID: 10.1002/ART.2434919248102) Haga HJ, Brun JG, Berntzen HB et al (1993) Calprotection in patients with systemic lupus erythematosus: relation to clinical and laboratory parameters of disease activity. Lupus 2:47–50. https://doi.org/10.1177/096120339300200108. (PMID: 10.1177/0961203393002001088485559) Demirbaş F, Çaltepe G, Comba A et al (2019) Fecal calprotectin in children with familial Mediterranean fever in the attack-free period. Pediatr Int 61:1140–1145. https://doi.org/10.1111/PED.13995. (PMID: 10.1111/PED.1399531446623) Tezcan D, Onmaz DE, Sivrikaya A et al (2023) Assessment of serum neopterin and calprotectin as biomarkers for subclinical inflammation in patients with familial Mediterranean fever. Ir J Med Sci 192:2015–2022. https://doi.org/10.1007/s11845-022-03173-w. (PMID: 10.1007/s11845-022-03173-w36163581) Bae SC, Lee YH (2017) Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis. Postgrad Med 129:531–537. https://doi.org/10.1080/00325481.2017.1319729. (PMID: 10.1080/00325481.2017.131972928425837) Jarlborg M, Courvoisier DS, Lamacchia C et al (2020) Serum calprotectin: a promising biomarker in rheumatoid arthritis and axial spondyloarthritis. Arthritis Res Ther 22:1–11. https://doi.org/10.1186/s13075-020-02190-3/tables/4. (PMID: 10.1186/s13075-020-02190-3/tables/4)
معلومات مُعتمدة:	2016/1208 Ankara Numune Egitim ve Arastirma Hastanesi
فهرسة مساهمة:	Keywords: Acute phase reactants; Attacks; Calprotectin; Familial Mediterranean fever; Rheumatoid arthritis
المشرفين على المادة:	0 (Leukocyte L1 Antigen Complex) 9007-41-4 (C-Reactive Protein) 0 (Biomarkers)
تواريخ الأحداث:	Date Created: 20240313 Date Completed: 20240801 Latest Revision: 20240801
رمز التحديث:	20240801
DOI:	10.1007/s11845-024-03659-9
PMID:	38478181
قاعدة البيانات:	MEDLINE

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تدمد:	1863-4362
DOI:	10.1007/s11845-024-03659-9