دورية أكاديمية
Occurrence of poliovirus and non-polio enterovirus among children with acute flaccid paralysis in Cameroon from 2015 to 2020.
| العنوان: | Occurrence of poliovirus and non-polio enterovirus among children with acute flaccid paralysis in Cameroon from 2015 to 2020. |
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| المؤلفون: | Njile DK; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Sadeuh-Mba SA; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Tabonfack Atemkeng M; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Ahanda A; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Momo JB; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Pekekue Nforifum R; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Etéré E; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Endegue-Zanga MC; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon., Boyomo O; Department of Microbiology University of Yaoundé 1, Yaoundé, Cameroon., Djoumetio MD; World Health Organization, Country Office, Yaoundé, Cameroon., Anfumbom Kfutwah J; World Health Organization, Regional Office BP: 820 - Libreville Gabon., Diop OM; The Polio Eradication Department, World Health Organization, Geneva 27, Switzerland., Njouom R; Virology Service, National Reference and Public Health Laboratory, Centre Pasteur of Cameroon, Yaoundé, Cameroon. |
| المصدر: | Journal of infection in developing countries [J Infect Dev Ctries] 2024 Feb 29; Vol. 18 (2), pp. 291-298. Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Italy?] : Open Learning on Enteric Pathogens |
| مواضيع طبية MeSH: | Poliovirus*/genetics , Enterovirus*/genetics , Poliomyelitis*/epidemiology , Enterovirus Infections*/epidemiology , Myelitis* , Neuromuscular Diseases* , Central Nervous System Viral Diseases*, Child ; Humans ; Cameroon/epidemiology ; alpha-Fetoproteins |
| مستخلص: | Introduction: Poliovirus (PV) and non-polio enteroviruses (NPEV) belong to the Picornaviridae family. They are found worldwide and are responsible for a wide range of diseases such as acute flaccid paralysis (AFP). This study aimed to evaluate the detection rate of PV and NPEV in stool samples from children under fifteen years of age presenting with AFP in Cameroon and their distribution over time. Methodology: Stool samples were collected as part of poliovirus surveillance throughout Cameroon from 2015 to 2020. Virus isolation was performed using RD and L20B cells maintained in culture. Molecular methods such as intratypic differentiation were used to identify PVs serotypes and analysis of the VP1 genome was performed. Results: A total of 12,354 stool samples were analyzed. The EV detection rate by virus isolation was 11.42% (1411/12354). This rate varied from year to year with a mean distribution of 11.41 with a 95% confidence interval [11.37; 11.44]. Of the viruses detected, suspected poliovirus accounted for 31.3% (442/1411) and NPEV 68.67% (969/1411). No wild poliovirus (WPV) was isolated. Sabin types 1 and 3 were continuously isolated. Surprisingly, from February 2020, vaccine-derived PV type 2 (VDPV2) was detected in 19% of cases, indicating its resurgence. Conclusions: This study strongly supports the successful elimination of WPV in Cameroon and the resurgence of VDPV2. However, as long as VDPV outbreaks continue to be detected in Africa, it remains essential to monitor how they spread. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Daniel K Njile, Serge A Sadeuh-Mba, Michel Tabonfack Atemkeng, Anicet Ahanda, Jean Blaise Momo, Raissa Pekekue Nforifum, Ernestine Etéré, Marie Claire Endegue-Zanga, Onana Boyomo, Marlise D Djoumetio, Jude Anfumbom Kfutwah, Ousmane M Diop, Richard Njouom.) |
| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| فهرسة مساهمة: | Keywords: Cameroon; Poliovirus; acute flaccid paralysis; enteroviruses |
| المشرفين على المادة: | 0 (alpha-Fetoproteins) |
| SCR Disease Name: | acute flaccid myelitis |
| تواريخ الأحداث: | Date Created: 20240314 Date Completed: 20240318 Latest Revision: 20240420 |
| رمز التحديث: | 20240420 |
| DOI: | 10.3855/jidc.18279 |
| PMID: | 38484358 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1972-2680 |
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| DOI: | 10.3855/jidc.18279 |