دورية أكاديمية
The amnesic shellfish poisoning toxin, domoic acid: The tattoo of the king scallop Pecten maximus.
| العنوان: | The amnesic shellfish poisoning toxin, domoic acid: The tattoo of the king scallop Pecten maximus. |
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| المؤلفون: | García-Corona JL; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France., Fabioux C; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France., Vanmaldergem J; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France., Petek S; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France., Derrien A; Littoral Ler Bo, Ifremer, Station de Biologie Marine, Place de la Croix, BP40537, Concarneau 29900 CEDEX, France., Terre-Terrillon A; Littoral Ler Bo, Ifremer, Station de Biologie Marine, Place de la Croix, BP40537, Concarneau 29900 CEDEX, France., Bressolier L; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France., Breton F; Écloserie du Tinduff, 148 rue de l'écloserie, Port du Tinduff, Plougastel-Daoulas 29470, France., Hegaret H; Laboratoire des Sciences de l'Environnement Marin, Institut Universitaire Européen de la Mer, UMR 6539 LEMAR UBO, CNRS, IRD, Ifremer, Plouzané F-29280, France. Electronic address: helene.hegaret@univ-brest.fr. |
| المصدر: | Harmful algae [Harmful Algae] 2024 Mar; Vol. 133, pp. 102607. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128968 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1470 (Electronic) Linking ISSN: 15689883 NLM ISO Abbreviation: Harmful Algae Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | Shellfish Poisoning* , Tattooing* , Pecten* , Pectinidae* , Diatoms*, Kainic Acid/*analogs & derivatives, Animals ; Humans ; Marine Toxins |
| مستخلص: | Domoic acid (DA) is a potent neurotoxin produced by diatoms of the genus Pseudo-nitzschia and is responsible for Amnesic Shellfish Poisoning (ASP) in humans. Some fishery resources of high commercial value, such as the king scallop Pecten maximus, are frequently exposed to toxic Pseudo-nitzschia blooms and are capable of accumulating high amounts of DA, retaining it for months or even a few years. This poses a serious threat to public health and a continuous economical risk due to fishing closures of this resource in the affected areas. Recently, it was hypothesized that trapping of DA within autophagosomic-vesicles could be one reason explaining the long retention of the remaining toxin in P. maximus digestive gland. To test this idea, we follow the kinetics of the subcellular localization of DA in the digestive glands of P. maximus during (a) the contamination process - with sequential samplings of scallops reared in the field during 234 days and naturally exposed to blooms of DA-producing Pseudo-nitzschia australis, and (b) the decontamination process - where highly contaminated scallops were collected after a natural bloom of toxic P. australis and subjected to DA-depuration in the laboratory for 60 days. In the digestive gland, DA-depuration rate (0.001 day -1 ) was much slower than contamination kinetics. The subcellular analyses revealed a direct implication of early autophagy in DA sequestration throughout contamination (r = 0.8, P < 0.05), while the presence of DA-labeled residual bodies (late autophagy) appeared to be strongly and significantly related to slow DA-depuration (r = -0.5) resembling an analogous DA-tattooing in the digestive glands of P. maximus. This work provides new evidence about the potential physiological mechanisms involved in the long retention of DA in P. maximus and represents the baseline to explore procedures to accelerate decontamination in this species. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Autophagy; Domoic acid; Pecten maximus; Rapid accumulation; Slow depuration; Toxicokinetics |
| المشرفين على المادة: | M02525818H (domoic acid) 0 (Marine Toxins) SIV03811UC (Kainic Acid) |
| تواريخ الأحداث: | Date Created: 20240314 Date Completed: 20240318 Latest Revision: 20240826 |
| رمز التحديث: | 20240826 |
| DOI: | 10.1016/j.hal.2024.102607 |
| PMID: | 38485441 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-1470 |
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| DOI: | 10.1016/j.hal.2024.102607 |