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Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study.
المؤلفون: Lee SS; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA. scott.lee@vumc.org., Senft Everson N; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Sanderson M; Meharry Medical College, Nashville, TN, USA., Selove R; Tennessee State University, Nashville, TN, USA., Blot WJ; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., King S; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Gilliam K; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Kundu S; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Steinwandel M; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Sternlieb SJ; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Cai Q; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Warren Andersen S; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA.; University of Wisconsin-Madison, University of Wisconsin Carbone Cancer Center, Madison, WI, USA., Friedman DL; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Connors Kelly E; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Fadden MK; Meharry Medical College, Nashville, TN, USA., Freiberg MS; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA.; Geriatric Research Education and Clinical Centers (GRECC), Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Wells QS; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA., Canedo J; Meharry Medical College, Nashville, TN, USA., Tyndale RF; Centre for Addiction and Mental Health, and Departments of Pharmacology & Toxicology, and Psychiatry, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, ON, Canada., Young RP; University of Auckland, Auckland, New Zealand., Hopkins RJ; University of Auckland, Auckland, New Zealand., Tindle HA; Vanderbilt University Medical Center, 2525 West End Ave. Suite 450, Nashville, TN, 37203, USA.; Geriatric Research Education and Clinical Centers (GRECC), Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.
المصدر: Addiction science & clinical practice [Addict Sci Clin Pract] 2024 Mar 15; Vol. 19 (1), pp. 16. Date of Electronic Publication: 2024 Mar 15.
نوع المنشور: Randomized Controlled Trial; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101316917 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-0640 (Electronic) Linking ISSN: 19400632 NLM ISO Abbreviation: Addict Sci Clin Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : London : BioMed Central
Original Publication: 2007-2011: Bethesda, MD : National Institute on Drug Abuse
مواضيع طبية MeSH: Smoking*/epidemiology , Smoking*/therapy , Tobacco Smoking*, Aged ; Humans ; Cohort Studies ; Feasibility Studies ; Pilot Projects ; Male ; Female
مستخلص: Background: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied.
Methods: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment.
Results: Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0-80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4-92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6-83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73-0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03-1.00, p = 0.050). No other selection effects were observed.
Conclusions: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling.
Trial Registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.
Clinicaltrials: gov/study/NCT03521141.
(© 2024. The Author(s).)
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معلومات مُعتمدة: T32 HS026122 United States HS AHRQ HHS; U54CA163069 United States CA NCI NIH HHS; K12HL137943 United States HL NHLBI NIH HHS; U54CA163066 United States CA NCI NIH HHS; U54CA163072-09S1 United States CA NCI NIH HHS; K12 HL137943 United States HL NHLBI NIH HHS; UL1TR002243 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Health disparities; Precision medicine; Smoking cessation treatment
سلسلة جزيئية: ClinicalTrials.gov NCT03521141
تواريخ الأحداث: Date Created: 20240316 Date Completed: 20240318 Latest Revision: 20240625
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC10941447
DOI: 10.1186/s13722-024-00441-1
PMID: 38491559
قاعدة البيانات: MEDLINE
الوصف
تدمد:1940-0640
DOI:10.1186/s13722-024-00441-1