دورية أكاديمية
Autoimmune blistering disorders and cardiovascular risks: A population-based cohort study.
| العنوان: | Autoimmune blistering disorders and cardiovascular risks: A population-based cohort study. |
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| المؤلفون: | Bonnesen K; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: bonnesen@clin.au.dk., Poulsen CFB; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiology, Gødstrup Regional Hospital, Herning, Denmark; Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark., Schmidt SAJ; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark., Sørensen HT; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Schmidt M; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiology, Gødstrup Regional Hospital, Herning, Denmark. |
| المصدر: | Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2024 Jul; Vol. 91 (1), pp. 82-90. Date of Electronic Publication: 2024 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 7907132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6787 (Electronic) Linking ISSN: 01909622 NLM ISO Abbreviation: J Am Acad Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: St. Louis, Mo., Mosby |
| مواضيع طبية MeSH: | Autoimmune Diseases*/epidemiology , Autoimmune Diseases*/complications , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/mortality, Humans ; Male ; Female ; Middle Aged ; Denmark/epidemiology ; Aged ; Adult ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Cohort Studies ; Heart Failure/epidemiology ; Pemphigus/epidemiology ; Pemphigus/complications ; Risk Assessment/statistics & numerical data ; Case-Control Studies ; Skin Diseases, Vesiculobullous/epidemiology ; Atherosclerosis/epidemiology ; Arrhythmias, Cardiac/epidemiology ; Aged, 80 and over ; Pemphigoid, Bullous/epidemiology ; Pemphigoid, Bullous/complications ; Heart Disease Risk Factors ; Young Adult |
| مستخلص: | Background: Autoimmune blistering disorders (ABDs) might elevate cardiovascular risk, but studies are lacking. Objective: The objective of this study was to examine if ABDs elevate the risk of atherosclerotic cardiovascular disease, heart failure, arrhythmia, venous thromboembolism, and cardiovascular death. Methods: A population-based cohort of Danish patients with ABD (≥18 years of age) diagnosed during 1996-2021 (n = 3322) was compared with an age- and sex-matched comparison cohort from the general population (n = 33,195). Results: Compared with the general population, patients with ABDs had higher 1-year risks of atherosclerotic cardiovascular disease (3.4% vs 1.6%), heart failure (1.9% vs 0.7%), arrhythmia (3.8% vs 1.3%), venous thromboembolism (1.9% vs 0.3%), and cardiovascular death (3.3% vs 0.9%). The elevated risk persisted after 10 years for all outcomes but arrhythmia. The hazard ratios associating ABDs with the outcomes during the entire follow-up were 1.24 (1.09-1.40) for atherosclerotic cardiovascular disease, 1.48 (1.24-1.77) for heart failure, 1.16 (1.02-1.32) for arrhythmia, 1.87 (1.50-2.34) for venous thromboembolism, and 2.01 (1.76-2.29) for cardiovascular death. The elevated cardiovascular risk was observed for both pemphigus and pemphigoid. Limitations: Our findings might only generalize to patients with ABDs without prevalent cardiovascular diseases. Conclusion: Patients with ABDs had an elevated cardiovascular risk compared with age- and sex-matched controls. Competing Interests: Conflicts of interest None disclosed. (Copyright © 2024 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: acute coronary syndrome; angina pectoris; angina, stable; angina, unstable; arrhythmias, cardiac; atrial fibrillation; atrioventricular block; autoimmune diseases; blister; cardiovascular diseases; epidemiology; heart arrest; heart failure; ischemic stroke; myocardial infarction; myocardial revascularization; pemphigoid, bullous; pemphigus; percutaneous coronary intervention; pulmonary embolism; venous thromboembolism; venous thrombosis |
| تواريخ الأحداث: | Date Created: 20240316 Date Completed: 20240621 Latest Revision: 20240621 |
| رمز التحديث: | 20240622 |
| DOI: | 10.1016/j.jaad.2024.02.052 |
| PMID: | 38492858 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1097-6787 |
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| DOI: | 10.1016/j.jaad.2024.02.052 |