دورية أكاديمية
أعرض في EDS

Evaluation of renal tubular function by multiparametric functional MRI in early diabetes.

التفاصيل البيبلوغرافية
العنوان: Evaluation of renal tubular function by multiparametric functional MRI in early diabetes.
المؤلفون: Wang R; Department of Radiology, Peking University First Hospital, Beijing, China., Lin Z; Department of Radiology, Peking University First Hospital, Beijing, China., Quan S; Department of Radiology, Peking University First Hospital, Beijing, China., Yang X; Department of Radiology, China Academy of Chinese Medical Sciences Guanganmen Hospital, Beijing, China., Zhao K; Department of Radiology, Peking University First Hospital, Beijing, China., Sui X; Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China., Kong H; UIH Group, Beijing United Imaging Research Institute of Intelligent Imaging, Beijing, China., Wang X; Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: wangxiaoying@bjmu.edu.cn., Su T; Department of Nephrology, Peking University First Hospital, Beijing, China. Electronic address: tao.su@bjmu.edu.cn.
المصدر: Magnetic resonance imaging [Magn Reson Imaging] 2024 Jun; Vol. 109, pp. 100-107. Date of Electronic Publication: 2024 Mar 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5894 (Electronic) Linking ISSN: 0730725X NLM ISO Abbreviation: Magn Reson Imaging Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Amsterdam : Elsevier
Original Publication: New York : Pergamon, c1982-
مواضيع طبية MeSH: Multiparametric Magnetic Resonance Imaging* , Diabetes Mellitus*/pathology, Animals ; Rabbits ; Furosemide/pharmacology ; Magnetic Resonance Imaging/methods ; Kidney/pathology ; Oxygen
مستخلص: Purpose To evaluate the tubular function in an alloxan-induced type 1 diabetes mellitus (DM) rabbit model measured by renal oxygenation (R2*), oxygen extraction fraction (OEF), and renal blood flow (RBF) using blood oxygenation level dependent, asymmetric spin echo, and arterial spin labeling MRI. Methods Twenty-six rabbits were randomized into the 3-day DM group (n = 13) and the 7-day DM group (n = 13). We performed pairs of multiparametric MRIs (before and after furosemide injection) at baseline and 3/7 days post-DM, and scored pathological kidney injury. We performed statistical analyses using non-parametric, chi-square, and Spearman correlation tests. Results At baseline, medullary R2* significantly decreased by 24.97% and 16.74% in the outer and inner stripes of the outer medulla (OS and IS, p = 0.006 and 0.003, respectively) after furosemide administration. While the corresponding OEF decreased by 15.91% for OS and 16.67% for IS (both p = 0.003), and no significant change in medullary RBF was observed (p > 0.05). In the 3-day DM group, the decrease of medullary R2* and OEF post-furosemide became unremarkable, suggesting tubular dysfunction. We noticed similar changes in the 7-day DM group. Correlation analysis showed pathological tubular injury score significantly correlated with medullary ∆R2* (post-furosemide - pre-furosemide difference, r = 0.82 for OS and 0.82 for IS) and ∆OEF (r = 0.82 for OS and 0.82 for IS) (p < 0.001, respectively). Conclusion: The combination of medullary OEF and R2* in response to furosemide could detect renal tubular dysfunction in early DM.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Diabetes mellitus; Furosemide; Magnetic resonance imaging; Oxygen consumption; Tubular dysfunction
المشرفين على المادة: 7LXU5N7ZO5 (Furosemide)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20240317 Date Completed: 20240409 Latest Revision: 20240426
رمز التحديث: 20240427
DOI: 10.1016/j.mri.2024.03.016
PMID: 38494095
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-5894
DOI:10.1016/j.mri.2024.03.016