دورية أكاديمية
أعرض في EDS

The α-1 Adrenergic Receptor Antagonist Doxazosin Attenuates Liver Fibrosis by Alleviating Sinusoidal Capillarization and Liver Angiogenesis.

التفاصيل البيبلوغرافية
العنوان: The α-1 Adrenergic Receptor Antagonist Doxazosin Attenuates Liver Fibrosis by Alleviating Sinusoidal Capillarization and Liver Angiogenesis.
المؤلفون: Xiu AY; Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China., Ding Q; Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China., Zhu CP; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China., Zhang CQ; Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.; Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
المصدر: Advanced biology [Adv Biol (Weinh)] 2024 Jun; Vol. 8 (6), pp. e2300513. Date of Electronic Publication: 2024 Mar 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH GmbH Country of Publication: Germany NLM ID: 101775319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2701-0198 (Electronic) Linking ISSN: 27010198 NLM ISO Abbreviation: Adv Biol (Weinh) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH GmbH, [2021]-
مواضيع طبية MeSH: Doxazosin*/pharmacology , Doxazosin*/therapeutic use , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Adrenergic alpha-1 Receptor Antagonists*/pharmacology , Adrenergic alpha-1 Receptor Antagonists*/therapeutic use , Human Umbilical Vein Endothelial Cells*/drug effects , Liver*/drug effects , Liver*/pathology , Liver*/blood supply , Neovascularization, Pathologic*/drug therapy , Neovascularization, Pathologic*/pathology, Animals ; Mice ; Humans ; Male ; Carbon Tetrachloride/toxicity ; Mice, Inbred C57BL ; Capillaries/drug effects ; Capillaries/pathology ; Disease Models, Animal ; Angiogenesis
مستخلص: Liver fibrosis and cirrhosis, which are caused by chronic liver injury, represent common and intractable clinical challenges of global importance. However, effective therapeutics are lacking. Therefore, the study examines the effect of doxazosin on liver fibrosis. Carbon tetrachloride (CCl 4 ) is injected into mice to establish a liver fibrosis model. Doxazosin (5 and 10 mg/kg) is administered daily by gavage. HE staining, Masson staining, Sirius Red staining, scanning electron microscopy, western blotting, real-time PCR, and immunofluorescence analysis are performed to estimate liver fibrosis and sinusoidal capillarization in mice. Cell Counting Kit-8 assays, western blotting, immunofluorescence analysis, tube formation, and transwell migration assays are performed on human umbilical vein endothelial cells (HUVECs) and human hepatic sinusoidal endothelial cells (HHSECs) to elucidate the potential mechanism of doxazosin. Doxazosin alleviates liver fibrosis and sinusoidal capillarization in CCl 4 -induced mice. Angiogenesis is attenuated by doxazosin in HUVECs and HHSECs. This study demonstrates that doxazosin attenuated liver fibrosis by alleviating sinusoidal capillarization and liver angiogenesis.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: 81770606 National Nature Foundation of China; 81970533 National Nature Foundation of China
فهرسة مساهمة: Keywords: angiogenesis; doxazosin; hepatic sinusoidal endothelial cell; liver fibrosis
المشرفين على المادة: NW1291F1W8 (Doxazosin)
0 (Adrenergic alpha-1 Receptor Antagonists)
CL2T97X0V0 (Carbon Tetrachloride)
تواريخ الأحداث: Date Created: 20240317 Date Completed: 20240614 Latest Revision: 20240627
رمز التحديث: 20240627
DOI: 10.1002/adbi.202300513
PMID: 38494421
قاعدة البيانات: MEDLINE
الوصف
تدمد:2701-0198
DOI:10.1002/adbi.202300513