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أعرض في EDS

Disrupting direct inputs from the dorsal subiculum to the granular retrosplenial cortex impairs flexible spatial memory in the rat.

التفاصيل البيبلوغرافية
العنوان: Disrupting direct inputs from the dorsal subiculum to the granular retrosplenial cortex impairs flexible spatial memory in the rat.
المؤلفون: Yanakieva S; School of Psychology, Cardiff University, Wales, UK., Frost BE; School of Psychology, Cardiff University, Wales, UK., Amin E; School of Psychology, Cardiff University, Wales, UK., Nelson AJD; School of Psychology, Cardiff University, Wales, UK., Aggleton JP; School of Psychology, Cardiff University, Wales, UK.
المصدر: The European journal of neuroscience [Eur J Neurosci] 2024 May; Vol. 59 (10), pp. 2715-2731. Date of Electronic Publication: 2024 Mar 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-
مواضيع طبية MeSH: Spatial Memory*/drug effects , Spatial Memory*/physiology , Hippocampus*/drug effects , Hippocampus*/physiology , Rats, Long-Evans*, Animals ; Male ; Rats ; Cues ; Clozapine/pharmacology ; Clozapine/analogs & derivatives ; Maze Learning/drug effects ; Maze Learning/physiology ; Neural Pathways/physiology ; Neural Pathways/drug effects ; Memory, Short-Term/drug effects ; Memory, Short-Term/physiology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology
مستخلص: In a changing environment, animals must process spatial signals in a flexible manner. The rat hippocampal formation projects directly upon the retrosplenial cortex, with most inputs arising from the dorsal subiculum and terminating in the granular retrosplenial cortex (area 29). The present study examined whether these same projections are required for spatial working memory and what happens when available spatial cues are altered. Consequently, injections of iDREADDs were made into the dorsal subiculum of rats. In a separate control group, GFP-expressing adeno-associated virus was injected into the dorsal subiculum. Both groups received intracerebral infusions within the retrosplenial cortex of clozapine, which in the iDREADDs rats should selectively disrupt the subiculum to retrosplenial projections. When tested on reinforced T-maze alternation, disruption of the subiculum to retrosplenial projections had no evident effect on the performance of those alternation trials when all spatial-cue types remained present and unchanged. However, the same iDREADDs manipulation impaired performance on all three alternation conditions when there was a conflict or selective removal of spatial cues. These findings reveal how the direct projections from the dorsal subiculum to the retrosplenial cortex support the flexible integration of different spatial cue types, helping the animal to adopt the spatial strategy that best meets current environmental demands.
(© 2024 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 108891/B/15/Z United Kingdom WT_ Wellcome Trust; 103722/Z14/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: Chemogenetics; Retrosplenial cortex; anatomy; dorsal subiculum; spatial memory; working memory
تواريخ الأحداث: Date Created: 20240318 Date Completed: 20240521 Latest Revision: 20240521
رمز التحديث: 20240521
DOI: 10.1111/ejn.16303
PMID: 38494604
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-9568
DOI:10.1111/ejn.16303