Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults.
| العنوان: | Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults. |
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| المؤلفون: | Jayaprakash HJ; Department of Bioengineering, University of Pittsburgh.; Department of Computer Science, University of Pittsburgh.; Center for Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh., Mizuno A; Department of Psychiatry, University of Pittsburgh., Snitz BE; Department of Neurology, University of Pittsburgh., Cohen AD; Department of Psychiatry, University of Pittsburgh., Klunk WE; Department of Psychiatry, University of Pittsburgh.; Department of Neurology, University of Pittsburgh., Aizenstein HJ; Department of Bioengineering, University of Pittsburgh.; Department of Psychiatry, University of Pittsburgh., Karim HT; Department of Bioengineering, University of Pittsburgh.; Department of Psychiatry, University of Pittsburgh. |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by changes in beta amyloid (Aß) and tau as well as changes in cerebral glucose metabolism and gray matter volume. This has been categorized as three distinct stages of amyloid, tau, and neurodegeneration. Past studies have shown asymmetric Aβ accumulation and its association with asymmetric cerebral metabolism in preclinical AD. We analyzed data to replicate these findings and extend them to associations with gray matter volume and cognitive function. Methods: We recruited 93 (mean age = 76.4±6.1 years) cognitively normal adults who underwent magnetic resonance imaging (MRI) and positron emission tomography (PET) with Pittsburgh compound B (PiB) and Fluorodeoxyglucose (FDG) tracers (to estimate Aβ and glucose metabolism, respectively). We conducted voxel-wise paired t-test on PiB (left vs. right hemispheres) to identify regions that differ in Aβ between the left and right cortex. We identified whether these regions showed asymmetry in FDG and gray matter volume using paired t-tests on each region. We then conducted correlations between asymmetry indices for each region that had significant asymmetry in PiB, FDG, and gray matter volume. We ran a group regression analysis on cognitive functions. Results: We found 26 regions that had significant rightward asymmetry in PiB including prefrontal cortex, temporal cortex, insula, parahippocampus, caudate, and putamen. All these regions showed significant gray matter rightward asymmetry, and most of these regions showed significant FDG asymmetry except the caudate, orbital cortex, medial frontal gyrus, and superior temporal gyrus. Only in the superior frontal gyrus, we found that greater rightward asymmetry in PiB was associated with greater rightward asymmetry in FDG, r (82) =0.38, p <0.005 (FDR corrected) - no other regions showed significant Aß asymmetry correlation with either FDG or gray matter volume asymmetry. We found that greater rightward FDG asymmetry in the superior frontal gyrus was associated with greater visuospatial processing scores in our cognitive domain group regression analysis. Discussion: AD has previously been modeled in three-stages: however, our results indicate that cerebral glucose metabolism may be dynamic throughout the disease progression and may serve as a compensatory pathway for maintaining cognitive functioning. |
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| معلومات مُعتمدة: | P01 AG025204 United States AG NIA NIH HHS; P50 AG005133 United States AG NIA NIH HHS; R37 AG025516 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: Alzheimer’s Disease; Asymmetry; Cognitive Function; FDG; Gray matter volume; PET; PiB |
| تواريخ الأحداث: | Date Created: 20240318 Latest Revision: 20240327 |
| رمز التحديث: | 20240327 |
| مُعرف محوري في PubMed: | PMC10942537 |
| DOI: | 10.1101/2024.03.05.24303808 |
| PMID: | 38496561 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2024.03.05.24303808 |
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