دورية أكاديمية
Association of urinary calcium excretion with chronic kidney disease in patients with type 2 diabetes.
| العنوان: | Association of urinary calcium excretion with chronic kidney disease in patients with type 2 diabetes. |
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| المؤلفون: | Wang Y; Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China., Chen Y; Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China., Yu Y; Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China., Pan X; Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China., Fu G; Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China. fuguoxiang818@163.com. |
| المصدر: | International urology and nephrology [Int Urol Nephrol] 2024 Aug; Vol. 56 (8), pp. 2715-2723. Date of Electronic Publication: 2024 Mar 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Springer Original Publication: Budapest, Akademiai Kiadó |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/urine , Diabetes Mellitus, Type 2*/complications , Renal Insufficiency, Chronic*/urine , Renal Insufficiency, Chronic*/epidemiology , Calcium*/urine, Humans ; Male ; Female ; Middle Aged ; Aged ; Glomerular Filtration Rate ; Albuminuria/urine ; Albuminuria/epidemiology ; Prevalence ; Cross-Sectional Studies ; Retrospective Studies ; Correlation of Data |
| مستخلص: | Purpose: Herein, we investigated the correlation between urinary calcium excretion (UCaE) and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). Methods: From August 2018 to January 2023, a total of 2031 T2DM patients providing 24-h urine samples were included in the final analyses. Patients were separated into four cohorts, based on the UCaE quartiles. We then analyzed renal functional indicators like estimated glomerular filtration rate (eGFR) and urinary albumin excretion (UAE) among the four groups. Lastly, we utilized multivariable logistic regression models to investigate the correlation between UCaE and CKD. Results: After adjusting for confounding factors, we observed a decreasing trend in CKD prevalence (36.3%, 13.0%, 7.5%, and 6.6%, respectively, P < 0.001) across the UCaE quartiles. Albuminuria (55.5% vs. 40.0%, 36.5%, 37.4%) and macroalbuminuria prevalence (20.0% vs. 9.3%, 5.2%, 5.7%) in the lowest quartile were markedly elevated, compared to the remaining three quartiles (P < 0.001). Meanwhile, the eGFR level (P < 0.001) showed a clearly increasing trend across the UCaE quartiles, and patients with moderate-to-severe decreases in eGFR levels (with cutoff limits at 30-59, 15-30, and < 15 mL/min/1.73m2) were mostly found in the lowest quartile (P < 0.001). Logistic regression analysis revealed that patients in the lowest quartile experienced an enhanced prevalence of CKD, relative to those in the highest quartile (odds ratio: 5.90, 95% confidence interval: 3.60-9.67, P < 0.001). Conclusion: Decreased UCaE was independently associated with the CKD prevalence in T2DM patients. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.) |
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| فهرسة مساهمة: | Keywords: Chronic kidney disease; Type 2 diabetes; Urinary calcium excretion |
| المشرفين على المادة: | SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20240318 Date Completed: 20240723 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| DOI: | 10.1007/s11255-024-03978-x |
| PMID: | 38498272 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2584 |
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| DOI: | 10.1007/s11255-024-03978-x |