دورية أكاديمية
Jujuboside A Attenuates Polycystic Ovary Syndrome Based on Estrogen Metabolism Through Activating AhR-mediated CYP1A2 Expression.
| العنوان: | Jujuboside A Attenuates Polycystic Ovary Syndrome Based on Estrogen Metabolism Through Activating AhR-mediated CYP1A2 Expression. |
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| المؤلفون: | Zhou N; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Lv W; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Chen L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Chen K; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., He Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Xie G; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Ma J; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China., Cao Y; Department of Obstetrics and Gynecology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, 199 South Jiefang Road, Xuzhou, 221004, China., Zhang B; Department of Obstetrics and Gynecology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, 199 South Jiefang Road, Xuzhou, 221004, China. bettyzhang10@163.com., Zhou X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China. zxy851107@xzhmu.edu.cn. |
| المصدر: | Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Aug; Vol. 31 (8), pp. 2234-2245. Date of Electronic Publication: 2024 Mar 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101291249 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-7205 (Electronic) Linking ISSN: 19337191 NLM ISO Abbreviation: Reprod Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [New York] : Springer Original Publication: Thousand Oaks, Calif. : Sage |
| مواضيع طبية MeSH: | Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/chemically induced , Polycystic Ovary Syndrome*/pathology , Receptors, Aryl Hydrocarbon*/metabolism , Estrogens*/pharmacology , Estrogens*/metabolism , Cytochrome P-450 CYP1A2*/metabolism, Female ; Animals ; Humans ; Mice ; Cytochrome P-450 CYP1A1/metabolism ; Ovary/drug effects ; Ovary/metabolism ; Ovary/pathology ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Disease Models, Animal ; Adult |
| مستخلص: | Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. This study aimed to investigate the therapeutic effects and mechanism of Jujuboside A on PCOS using a dehydroepiandrosterone (DHEA)-induced PCOS mouse model. Estrogen and androgen homeostasis was evaluated in serum from both clinical samples and PCOS mice. The stages of the estrous cycle were determined based on vaginal cytology. The ovarian morphology was observed by stained with hematoxylin and eosin. Moreover, we analyzed protein expression of cytochrome P450 1A1 (CYP1A1), cytochrome P450 1A2 (CYP1A2) and aryl hydrocarbon receptor (AhR) in ovary and KGN cells. Molecular docking, immunofluorescence, and luciferase assay were performed to confirm the activation of AhR by Jujuboside A. Jujuboside A effectively alleviated the disturbance of estrogen homeostasis and restored ovarian function, leading to an improvement in the occurrence and progression of PCOS. Furthermore, the protective effect of JuA against PCOS was dependent on increased CYP1A2 levels regulated by AhR. Our findings suggest that Jujuboside A improves estrogen disorders and may be a potential therapeutic agent for the treatment of PCOS. (© 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.) |
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| معلومات مُعتمدة: | KC23255 Science and Technology Foundation of Xuzhou; 18KA350002 Natural Science Foundation of the Jiangsu Higher Education Institutions of China; H2017079 Provincial Commission of Health and Family Planning in Jiangsu Province; BE2019636 Science and Technology Planning Project of Jiangsu Province; 82173883 Natural Science Foundation of China; MS2023175 the administration of Traditional Chinese Medicine in Jiangsu Province |
| فهرسة مساهمة: | Keywords: Aryl hydrocarbon receptor; CYP1A2; Estrogen metabolism; Hormone homeostasis; Jujuboside A; Polycystic ovary syndrome |
| المشرفين على المادة: | 0 (Receptors, Aryl Hydrocarbon) 0 (Estrogens) EC 1.14.14.1 (Cytochrome P-450 CYP1A2) EC 1.14.14.1 (Cytochrome P-450 CYP1A1) 0 (AHR protein, human) 0 (Basic Helix-Loop-Helix Transcription Factors) EC 1.14.14.1 (CYP1A2 protein, human) |
| تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240730 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1007/s43032-024-01511-0 |
| PMID: | 38499949 |
| قاعدة البيانات: | MEDLINE |
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