دورية أكاديمية
أعرض في EDS

Unraveling the Clinicopathological Diversity and Subtypes of Rhabdomyosarcoma: A Study From a Tertiary Care Center.

التفاصيل البيبلوغرافية
العنوان: Unraveling the Clinicopathological Diversity and Subtypes of Rhabdomyosarcoma: A Study From a Tertiary Care Center.
المؤلفون: Mandava H; Pathology, NRI Medical College, Chinakakani, IND., Venkata Renuka I; Pathology, NRI Medical College, Chinakakani, IND., Ramamoorthy S; Pathology, NRI Medical College, Chinakakani, IND.
المصدر: Cureus [Cureus] 2024 Feb 17; Vol. 16 (2), pp. e54341. Date of Electronic Publication: 2024 Feb 17 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Background and objective Rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor characterized by skeletal muscle differentiation. While it is a common soft tissue sarcoma in children, its incidence significantly decreases with advancing age, rendering it exceptionally rare in individuals aged more than 45 years. This study aimed to shed light on the clinicopathological diversity and subtypes of RMS, thereby providing a comprehensive overview for enabling diagnostic precision and therapeutic strategies in treating this infrequently encountered malignancy in adults. Methodology This was a hospital-based cross-sectional study conducted in the Department of Pathology. Patients who were diagnosed with RMS over a period of three years were included in the study. The demographic features such as age and sex and aspects related to the tumor site, size, subtypes of RMS, and immunohistochemical expression were studied. Results A total of 14 cases were included in our study. The age at diagnosis ranged from four months to 65 years with a male-to-female ratio of 1:2.5. The sites of presentation were head and neck, trunk, pelvis, genitourinary tract, and retroperitoneum. The histological types were embryonal, alveolar, pleomorphic, and mixed and spindle cell types. The tumor cells were positive for immunohistochemistry markers desmin, MyoD1, and vimentin. Conclusion This study delved into the clinicopathological intricacies of RMS, offering comprehensive insights into its diverse subtypes. Our findings underscore the unique presentation of RMS in adults, with trunk and genitourinary tracts emerging as primary sites and alveolar and pleomorphic RMS observed as the predominant histological subtypes. Furthermore, the study sheds light on rare subtypes with distinct anatomical distributions.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Mandava et al.)
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فهرسة مساهمة: Keywords: alveolar rhabdomyosarcoma; embryonal rhabdomyosarcoma; myo d1; pleomorphic rhabdomyosarcoma; rhabdomyosarcoma (rms); spindle cell rhabdomyosarcoma
تواريخ الأحداث: Date Created: 20240319 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC10945286
DOI: 10.7759/cureus.54341
PMID: 38500901
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.54341