دورية أكاديمية
Health benefits of fraxetin: From chemistry to medicine.
| العنوان: | Health benefits of fraxetin: From chemistry to medicine. |
|---|---|
| المؤلفون: | Ha NM; Faculty of Chemical Technology, Hanoi University of Industry, Hanoi, Vietnam., Son NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Department of Chemistry, Graduate University of Science and Technology, VAST, Hanoi, Vietnam. |
| المصدر: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Jul; Vol. 357 (7), pp. e2400092. Date of Electronic Publication: 2024 Mar 19. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA Original Publication: Weinheim, Verlag Chemie GmbH. |
| مواضيع طبية MeSH: | Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/chemical synthesis, Humans ; Animals ; Signal Transduction/drug effects ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/chemical synthesis |
| مستخلص: | Fraxetin is a bioactive molecule present in various natural plants, especially Cortex Fraxini. Evidenced outcomes in phytochemical and biological analyses for this agent are now available in the literature, but an insightful review is yet unknown. The goal of the current research is to offer a panoramic illustration of natural observation, biosynthesis, synthesis, pharmacology, and pharmacokinetics for fraxetin. Esculetin and ferulic acid acted as precursors in the enzymatic biosynthetic route, whereas fraxetin could be easily synthesized from simple phenols. A great deal of interest was obtained in using this molecule for pharmacological targets. Herein, its pharmacological value included anticancer, antioxidative, anti-inflammatory, antidiabetic, antiobesity, and antimicrobial activities, as well as the protection of the liver, neurons, heart, bone, lung, kidney, and others. Anticancer activity may involve the inhibition of proliferation, invasion, and migration, together with apoptotic induction. Health benefits from this molecule were deduced from its ability to suppress cytokines and protect the immune syndrome. Various signaling pathways, such as Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3), phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt), nuclear factor kappa B (NF-κB)/NLRP3, Akt/AMPK, have been proposed for in vitro and in vivo mechanisms of action. Fraxetin is highly distributed to rat plasma and several organs. However, more pharmacokinetic studies to improve its bioavailability are needed since its solubility in water is still limited. (© 2024 Deutsche Pharmazeutische Gesellschaft.) |
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| معلومات مُعتمدة: | None |
| فهرسة مساهمة: | Keywords: fraxetin; pharmacokinetics; pharmacology; phytochemistry |
| المشرفين على المادة: | CD3GD44O3K (fraxetin) 0 (Coumarins) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1002/ardp.202400092 |
| PMID: | 38501886 |
| قاعدة البيانات: | MEDLINE |
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