دورية أكاديمية
أعرض في EDS

Whey Protein Isolate Composites as Potential Scaffolds for Cultivated Meat.

التفاصيل البيبلوغرافية
العنوان: Whey Protein Isolate Composites as Potential Scaffolds for Cultivated Meat.
المؤلفون: Charron PN; Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States., Tahir I; Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States., Foley C; Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States., White G; Department of Electrical and Biomedical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States., Floreani RA; Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States.; Department of Electrical and Biomedical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, Vermont 05405, United States.; Materials Science Program, University of Vermont, Burlington, Vermont 05405, United States.; Food Systems Program, University of Vermont, Burlington, Vermont 05405, United States.
المصدر: ACS applied bio materials [ACS Appl Bio Mater] 2024 Apr 15; Vol. 7 (4), pp. 2153-2163. Date of Electronic Publication: 2024 Mar 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : ACS Publications, [2018]-
مواضيع طبية MeSH: In Vitro Meat* , Tissue Scaffolds*, Animals ; Humans ; Whey Proteins ; Hydrogels ; Alginates
مستخلص: Modern food technology has given rise to numerous alternative protein sources in response to a growing human population and the negative environmental impacts of current food systems. To aid in achieving global food security, one such form of alternative protein being investigated is cultivated meat, which applies the principles of mechanical and tissue engineering to produce animal proteins and meat products from animal cells. Herein, nonmodified and methacrylated whey protein formed hydrogels with methacrylated alginate as potential tissue engineering scaffolds for cultivated meat. Whey protein is a byproduct of dairy processing and was selected because it is an approved food additive and cytocompatible and has shown efficacy in other biomaterial applications. Whey protein and alginate scaffolds were formed via visible light cross-linking in aqueous solutions under ambient conditions. The characteristics of the precursor solution and the physical-mechanical properties of the scaffolds were quantified; while gelation occurred within the homo- and copolymer hydrogels, the integrity of the network was significantly altered with varying components. Qualitatively, the scaffolds exhibited a three-dimensional (3D) interconnected porous network. Whey protein isolate (WPI)-based scaffolds were noncytotoxic and supported in vitro myoblast adhesion and proliferation. The data presented support the hypothesis that the composition of the hydrogel plays a significant role in the scaffold's performance.
فهرسة مساهمة: Keywords: alginate; cultivated meat; dairy protein; polysaccharide; scaffold; whey protein isolate
المشرفين على المادة: 0 (Whey Proteins)
0 (Hydrogels)
0 (Alginates)
تواريخ الأحداث: Date Created: 20240319 Date Completed: 20240416 Latest Revision: 20240612
رمز التحديث: 20240613
DOI: 10.1021/acsabm.3c00944
PMID: 38502811
قاعدة البيانات: MEDLINE
الوصف
تدمد:2576-6422
DOI:10.1021/acsabm.3c00944