دورية أكاديمية
Utility of coronary revascularization in patients with ischemic left ventricular dysfunction.
| العنوان: | Utility of coronary revascularization in patients with ischemic left ventricular dysfunction. |
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| المؤلفون: | Al-Sadawi M; Division of Cardiology, University of Michigan Hospital, Ann Arbor, MI, USA. Electronic address: moalsada@med.umich.edu., Tao M; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Dhaliwal S; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Radakrishnan A; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Liu Y; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Gier C; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Masson R; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Rahman T; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Tam E; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA., Mann N; Department of Medicine, Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY, USA. |
| المصدر: | Cardiovascular revascularization medicine : including molecular interventions [Cardiovasc Revasc Med] 2024 Aug; Vol. 65, pp. 88-97. Date of Electronic Publication: 2024 Mar 05. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101238551 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0938 (Electronic) Linking ISSN: 18780938 NLM ISO Abbreviation: Cardiovasc Revasc Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, c2005- |
| مواضيع طبية MeSH: | Coronary Artery Bypass*/adverse effects , Coronary Artery Bypass*/mortality , Percutaneous Coronary Intervention*/adverse effects , Percutaneous Coronary Intervention*/mortality , Ventricular Dysfunction, Left*/diagnostic imaging , Ventricular Dysfunction, Left*/mortality , Ventricular Dysfunction, Left*/physiopathology , Ventricular Dysfunction, Left*/surgery , Ventricular Function, Left*, Aged ; Female ; Humans ; Male ; Middle Aged ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery ; Recovery of Function ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome |
| مستخلص: | Background: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of revascularization using percutaneous coronary intervention (PCI) versus coronary-artery bypass grafting (CABG). Objectives: The purpose of this meta-analysis is to evaluate the association of coronary revascularization with outcomes in patients with ischemic LV dysfunction. Methods: A literature search was conducted for studies reporting on cardiovascular outcomes after revascularization compared to optimal medical therapy (OMT) in patients with ischemic LV dysfunction. Results: A total of 23 studies with 10,110 participants met inclusion criteria. Revascularization was significantly associated with lower all-cause mortality and CV mortality compared to OMT. The association was statistically significant regardless of severity of LV dysfunction or method of revascularization. Subgroup analysis demonstrated that revascularization was significantly associated with lower all-cause and CV mortality compared to OMT for patients with viable myocardium and mixed cohorts with variable viability, but not patients without viable myocardium. Revascularization was not associated with a significant difference in risk of heart failure (HF) hospitalization or acute myocardial infarction (AMI) compared to OMT. Conclusions: Revascularization in patients with ischemic LV dysfunction is associated with lower risk of all-cause and CV mortality independent of severity of LV dysfunction or method of revascularization. Revascularization is not associated with lower risk of mortality in patients without evidence of viable myocardium and is not associated with lower risk of AMI or HF hospitalization. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ischemic cardiomyopathy; Percutaneous coronary intervention; Revascularization; Severe left ventricular dysfunction |
| تواريخ الأحداث: | Date Created: 20240319 Date Completed: 20240717 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1016/j.carrev.2024.02.021 |
| PMID: | 38503643 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-0938 |
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| DOI: | 10.1016/j.carrev.2024.02.021 |