دورية أكاديمية
أعرض في EDS

No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes.

التفاصيل البيبلوغرافية
العنوان: No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes.
المؤلفون: Andresen K; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Klæboe LG; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway.; Department of Cardiology, Akershus University Hospital, Lørenskog, Norway., Lie ØH; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway., Broch K; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Kvaslerud AB; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Bosse G; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Hopp E; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway., de Lange C; Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Pediatric Radiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden., Haugaa KH; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Heart and Lung Diseases Unit, Department of Medicine, Karolinska University Hospital, Huddinge, Sweden., Edvardsen T; ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, P. O. Box 4950, N-0424, Oslo, Norway. thor.edvardsen@medisin.uio.no.; Faculty of Medicine, University of Oslo, Oslo, Norway. thor.edvardsen@medisin.uio.no.
المصدر: Scientific reports [Sci Rep] 2024 Mar 19; Vol. 14 (1), pp. 6581. Date of Electronic Publication: 2024 Mar 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Contrast Media* , Cardiomyopathies*/pathology, Adult ; Humans ; Male ; Child ; Cross-Sectional Studies ; Gadolinium ; Myocardium/pathology ; Fibrosis ; Athletes ; Magnetic Resonance Imaging, Cine ; Predictive Value of Tests ; Ventricular Function, Left ; Stroke Volume
مستخلص: The potential association between endurance exercise and myocardial fibrosis is controversial. Data on exercise exposure and diffuse myocardial fibrosis in endurance athletes are scarce and conflicting. We aimed to investigate the association between exercise exposure and markers of diffuse myocardial fibrosis by cardiovascular magnetic resonance imaging (CMR) in endurance athletes. We examined 27 healthy adult male competitive endurance athletes aged 41 ± 9 years and 16 healthy controls in a cross sectional study using 3 Tesla CMR including late gadolinium enhancement and T1 mapping. Athletes reported detailed exercise history from 12 years of age. Left ventricular total mass, cellular mass and extracellular mass were higher in athletes than controls (86 vs. 58 g/m 2 , 67 vs. 44 g/m 2 and 19 vs. 13 g/m 2 , all p < 0.01). Extracellular volume (ECV) was lower (21.5% vs. 23.8%, p = 0.03) and native T1 time was shorter (1214 ms vs. 1268 ms, p < 0.01) in the athletes. Increasing exercise dose was independently associated with shorter native T1 time (regression coefficient - 24.1, p < 0.05), but expressed no association with ECV. Our results indicate that diffuse myocardial fibrosis has a low prevalence in healthy male endurance athletes and do not indicate an adverse dose-response relationship between exercise and diffuse myocardial fibrosis in healthy athletes.
(© 2024. The Author(s).)
References: J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75. (PMID: 28992817)
J Am Heart Assoc. 2015 Dec 18;4(12):. (PMID: 26683218)
BMJ Open Sport Exerc Med. 2018 Oct 25;4(1):e000422. (PMID: 30498573)
Clin Cardiol. 2020 Aug;43(8):882-888. (PMID: 32189357)
Heart. 2009 Sep;95(17):1409-14. (PMID: 19443476)
Int J Cardiovasc Imaging. 2016 Jun;32(6):975-81. (PMID: 26920720)
Curr Treat Options Cardiovasc Med. 2018 Aug 31;20(10):86. (PMID: 30167977)
JACC Cardiovasc Imaging. 2016 Jan;9(1):54-63. (PMID: 26762875)
Lancet. 1992 Sep 19;340(8821):712-4. (PMID: 1355810)
Mayo Clin Proc. 2016 Nov;91(11):1617-1631. (PMID: 27720455)
Circulation. 2014 Sep 16;130(12):992-1002. (PMID: 25223770)
Eur Heart J. 2008 Aug;29(15):1903-10. (PMID: 18426850)
Med Sci Sports Exerc. 2011 Aug;43(8):1575-81. (PMID: 21681120)
Eur J Radiol. 2018 Dec;109:223-234. (PMID: 30539758)
Radiology. 2009 Apr;251(1):50-7. (PMID: 19332846)
J Cardiovasc Magn Reson. 2020 Mar 12;22(1):19. (PMID: 32160925)
Eur Heart J. 2012 Apr;33(8):998-1006. (PMID: 22160404)
JACC Cardiovasc Imaging. 2013 Sep;6(9):993-1007. (PMID: 24029371)
J Cardiovasc Magn Reson. 2018 Jun 28;20(1):46. (PMID: 29950178)
BMC Med Imaging. 2010 Jan 11;10:1. (PMID: 20064248)
JACC Cardiovasc Imaging. 2018 Sep;11(9):1260-1270. (PMID: 29248656)
Circ Cardiovasc Imaging. 2016 Apr;9(4):e003579. (PMID: 27033835)
J Am Coll Cardiol. 2016 Jan 26;67(3):316-29. (PMID: 26796398)
Clin J Sport Med. 2022 May 1;32(3):e230-e242. (PMID: 34009785)
Med Sci Sports Exerc. 2020 Dec;52(12):2500-2507. (PMID: 32472930)
Circulation. 2017 Dec 19;136(25):2519-2521. (PMID: 29255128)
Circulation. 2016 Jun 7;133(23):2297-313. (PMID: 27267537)
J Cardiovasc Transl Res. 2020 Jun;13(3):296-305. (PMID: 32436168)
Eur Heart J. 2021 Jan 1;42(1):17-96. (PMID: 32860412)
Eur J Radiol. 2018 Dec;109:235-247. (PMID: 30539759)
JACC Cardiovasc Imaging. 2021 Jan;14(1):148-158. (PMID: 33129723)
BMJ Open Sport Exerc Med. 2022 Mar 18;8(1):e001309. (PMID: 35368514)
J Cardiovasc Magn Reson. 2014 Jan 04;16:2. (PMID: 24387626)
J Appl Physiol (1985). 2011 Jun;110(6):1622-6. (PMID: 21330616)
Circ Arrhythm Electrophysiol. 2016 Jul;9(7):. (PMID: 27390211)
Eur J Radiol. 2019 Aug;117:89-94. (PMID: 31307657)
JACC Cardiovasc Imaging. 2019 Sep;12(9):1755-1765. (PMID: 30553678)
Eur Heart J. 2018 Jun 1;39(21):1949-1969. (PMID: 29029207)
J Cardiovasc Magn Reson. 2020 Sep 3;22(1):62. (PMID: 32878630)
Circulation. 2010 Aug 17;122(7):743-52. (PMID: 20713909)
Invest Radiol. 2021 Nov 1;56(11):764-772. (PMID: 34261084)
Eur Heart J Cardiovasc Imaging. 2016 Jul;17(7):797-803. (PMID: 26358692)
Circulation. 2017 Jul 11;136(2):126-137. (PMID: 28465287)
معلومات مُعتمدة: 2017207 South-Eastern Norway Regional Health Authority; 309762 Research Council of Norway
المشرفين على المادة: 0 (Contrast Media)
AU0V1LM3JT (Gadolinium)
تواريخ الأحداث: Date Created: 20240320 Date Completed: 20240321 Latest Revision: 20240323
رمز التحديث: 20240323
مُعرف محوري في PubMed: PMC10951320
DOI: 10.1038/s41598-024-57233-5
PMID: 38503845
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-57233-5