دورية أكاديمية
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Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.

التفاصيل البيبلوغرافية
العنوان: Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.
المؤلفون: Yadav-Samudrala BJ; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Gorman BL; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Barmada KM; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Ravula HP; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Huguely CJ; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Wallace ED; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Peace MR; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States., Poklis JL; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States., Jiang W; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States., Fitting S; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
المصدر: Frontiers in neuroscience [Front Neurosci] 2024 Mar 05; Vol. 18, pp. 1358555. Date of Electronic Publication: 2024 Mar 05 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Background: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined acute CBD effects on various behaviors and the endocannabinoid system in HIV Tat transgenic mice.
Methods: Tat transgenic mice (female/male) were injected with CBD (3, 10, 30 mg/kg) and assessed for antinociception, activity, coordination, anxiety-like behavior, and recognition memory. Brains were taken to quantify endocannabinoids, cannabinoid receptors, and cannabinoid catabolic enzymes. Additionally, CBD and metabolite 7-hydroxy-CBD were quantified in the plasma and cortex.
Results: Tat decreased supraspinal-related nociception and locomotion. CBD and sex had little to no effects on any of the behavioral measures. For the endocannabinoid system male sex was associated with elevated concentration of the proinflammatory metabolite arachidonic acid in various CNS regions, including the cerebellum that also showed higher FAAH expression levels for Tat(+) males. GPR55 expression levels in the striatum and cerebellum were higher for females compared to males. CBD metabolism was altered by sex and Tat expression.
Conclusion: Findings indicate that acute CBD effects are not altered by HIV Tat, and acute CBD has no to minimal effects on behavior and the endocannabinoid system.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Yadav-Samudrala, Gorman, Barmada, Ravula, Huguely, Wallace, Peace, Poklis, Jiang and Fitting.)
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معلومات مُعتمدة: R01 DA055523 United States DA NIDA NIH HHS; R21 DA057871 United States DA NIDA NIH HHS; T32 DA007244 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: 2-arachidonoylglycerol; FAAH; GPR55; Tat transgenic mice; antinociception; arachidonic acid; cannabidiol
تواريخ الأحداث: Date Created: 20240320 Latest Revision: 20240521
رمز التحديث: 20240521
مُعرف محوري في PubMed: PMC10949733
DOI: 10.3389/fnins.2024.1358555
PMID: 38505774
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-4548
DOI:10.3389/fnins.2024.1358555