دورية أكاديمية
Plasma bile acids in association with Crohn's disease.
| العنوان: | Plasma bile acids in association with Crohn's disease. |
|---|---|
| المؤلفون: | Kiasat A; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.; Colorectal Surgery Unit, Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden., Prast-Nielsen S; Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden.; Science for Life Laboratory, Stockholm, Sweden., Rautiainen S; Global and Sexual Health Research Group, Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden., Engstrand L; Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden.; Science for Life Laboratory, Stockholm, Sweden., Andersson F; Department of Chemical and Pharmaceutical Safety, Research Institutes of Sweden (RISE), Sweden., Lindberg J; Department of Chemical and Pharmaceutical Safety, Research Institutes of Sweden (RISE), Sweden., Schuppe-Koistinen I; Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden.; Science for Life Laboratory, Stockholm, Sweden., Löf Granström A; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Gustafsson UO; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.; Colorectal Surgery Unit, Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden. |
| المصدر: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2024 Jun; Vol. 59 (6), pp. 674-682. Date of Electronic Publication: 2024 Mar 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0060105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7708 (Electronic) Linking ISSN: 00365521 NLM ISO Abbreviation: Scand J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo : Universitetsforlager |
| مواضيع طبية MeSH: | Crohn Disease*/blood , Bile Acids and Salts*/blood, Humans ; Male ; Female ; Cross-Sectional Studies ; Adult ; Middle Aged ; Case-Control Studies ; Sweden ; Colonoscopy ; Linear Models ; Severity of Illness Index ; Young Adult |
| مستخلص: | Background: In addition to facilitating lipid digestions, bile acids (BA) are signalling molecules acting on receptors on immune cells and along the gastrointestinal (GI) tract. The aim of this study was to assess if altered bile acid profiles in plasma are associated with Crohn's disease (CD). Method: This cross-sectional study included individuals (aged ≥18 years) referred for colonoscopy at a tertiary centre in Stockholm between 2016 and 2019. All participants received bowel preparation, completed a lifestyle questionnaire and provided blood samples for analysis. During colonoscopy, severity of disease was graded, and biopsies were taken from colonic mucosa. In the current substudy, 88 individuals with CD and 88 age-matched controls were selected for analysis of BA in plasma with ultra performance liquid chromatography (UPLC). Linear regression models were then used to compare mean bile acid concentrations and concentration ratios between CD and controls. Results: Individuals with CD had lower plasma concentrations of the majority of secondary BA compared to controls, in total CD/CC ratio 0.60 (SE 0.12), p = 0.001. The most prominent observations were lower levels of deoxycolic acid derivates and lithocolic acid derivates among participants with CD. Moreover, plasma concentration for secondary BA among participants with active CD was significantly lower compared to those with CD in remission, CD active/CD remission ratio 0.65 (SE 0.11), p < 0.002. Conclusion: Crohn's disease may be associated with altered plasma bile acid composition. The significance of colonic bacterial diversity in this context needs to be investigated in further studies. |
| فهرسة مساهمة: | Keywords: Crohn’s disease; Inflammatory bowel disease; bile acid; microbiota Local Abstract: [plain-language-summary] It is known that Crohn’s disease is associated with dysbiosis in the gut microbiota and that primary bile acids are transformed to secondary bile acids by bacterial enzymes in the gut before reabsorbed and transported back to the liver.In this cross-sectional study, Crohn’s disease was associated with lower concentrations of secondary bile acids in blood plasmaThe findings should encourage further studies the role of the gut microbiome and bile acid metabolism in development of Crohn’s disease and bile acid profile as a biomarker for bowel inflammation. |
| المشرفين على المادة: | 0 (Bile Acids and Salts) |
| تواريخ الأحداث: | Date Created: 20240320 Date Completed: 20240528 Latest Revision: 20240528 |
| رمز التحديث: | 20240529 |
| DOI: | 10.1080/00365521.2024.2328592 |
| PMID: | 38505982 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7708 |
|---|---|
| DOI: | 10.1080/00365521.2024.2328592 |