دورية أكاديمية
Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease.
| العنوان: | Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease. |
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| المؤلفون: | Kishi S; Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, 7010192, Japan. seiji.kishi@med.kawasaki-m.ac.jp., Nakashima T; TXP Medical Co. Ltd, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan., Goto T; TXP Medical Co. Ltd, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan. tag695@mail.harvard.edu.; Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan. tag695@mail.harvard.edu., Nagasu H; Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, 7010192, Japan., Brooks CR; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA., Okada H; Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Tamura K; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Nakano T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Narita I; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Maruyama S; Department of Nephrology, Nagoya University Graduate School of Medicine, Aichi, Japan., Yano Y; Department of Advanced Epidemiology, NCD Epidemiology Research Center, Shiga University of Medical Science, Shiga, Japan., Yokoo T; Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan., Wada T; Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan., Wada J; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Nangaku M; Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Kashihara N; Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, 7010192, Japan. |
| المصدر: | Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Aug; Vol. 28 (8), pp. 784-792. Date of Electronic Publication: 2024 Mar 20. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Japan NLM ID: 9709923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7799 (Electronic) Linking ISSN: 13421751 NLM ISO Abbreviation: Clin Exp Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2008- : Tokyo : Springer Original Publication: Tokyo : Published for the Japanese Society of Nephrology by Churchill Livingstone, c1997- |
| مواضيع طبية MeSH: | Magnesium*/blood , Renal Insufficiency, Chronic*/blood , Renal Insufficiency, Chronic*/physiopathology , Renal Insufficiency, Chronic*/diagnosis , Disease Progression* , Glomerular Filtration Rate*, Humans ; Male ; Female ; Middle Aged ; Prognosis ; Aged ; Prospective Studies ; Magnesium Deficiency/blood ; Magnesium Deficiency/complications ; Japan/epidemiology ; Kidney/physiopathology |
| مستخلص: | Background: Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis of renal function in CKD patients. Methods: This is an analysis of the Japan Chronic Kidney Disease Database Ex (J-CKD-DB-Ex), which is a multicenter prospective cohort including CKD patients enrolled from January 1, 2014 to December 31, 2020. We included adult outpatients with CKD stage G3 and G4 at the time of initial magnesium measurement. Patients were classified by magnesium levels as low (<1.7 mg/dl), normal (1.7-2.6 mg/dl), or high (>2.6 mg/dl). The primary outcomes were the composite of an eGFR < 15 ml/min/1.73 m 2 or a ≥30% reduction in eGFR from the initial measurement, which was defined as CKD progression. We applied the Kaplan-Meier analysis and Cox regression hazard model to examine the association between magnesium levels and CKD progression. Results: The analysis included 9868 outpatients during the follow-up period. The low magnesium group was significantly more likely to reach CKD progression. Cox regression, adjusting for covariates and using the normal magnesium group as the reference, showed that the hazard ratio for the low magnesium group was 1.20 (1.08-1.34). High magnesium was not significantly associated with poor renal outcomes compared with normal magnesium. Conclusion: Based on large real-world data, this study demonstrated that low magnesium levels are associated with poorer renal outcomes. (© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.) |
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| معلومات مُعتمدة: | R05B111 Kawasaki Medical School; 22ek0210135h0001 Japan Agency for Medical Research and Development |
| فهرسة مساهمة: | Keywords: CKD; Hypomagnesemia; J-CKD-DB-Ex; Magnesium; Real world data |
| المشرفين على المادة: | I38ZP9992A (Magnesium) |
| تواريخ الأحداث: | Date Created: 20240320 Date Completed: 20240723 Latest Revision: 20240913 |
| رمز التحديث: | 20240914 |
| DOI: | 10.1007/s10157-024-02486-7 |
| PMID: | 38506982 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1437-7799 |
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| DOI: | 10.1007/s10157-024-02486-7 |