دورية أكاديمية
أعرض في EDS

Longitudinal analysis of CSF HIV RNA in untreated people with HIV: Identification of CSF controllers.

التفاصيل البيبلوغرافية
العنوان: Longitudinal analysis of CSF HIV RNA in untreated people with HIV: Identification of CSF controllers.
المؤلفون: Trunfio M; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA.; Department of Medical Sciences, University of Turin, Turin, Italy., Tang B; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Okwuegbuna O; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Iudicello JE; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Bharti A; Division of Infectious Diseases and Global Health, University of California San Diego, San Diego, California, USA., Moore DJ; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Gelman BB; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Morgello S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Patel PB; Department of Neurology, University of Washington, Seattle, Washington, USA., Rubin LH; Department of Neurology, Psychiatry and Behavioral Sciences, Molecular and Cellular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ances BM; Department of Neurology, Washington University, St Louis, Missouri, USA., Gianella S; Division of Infectious Diseases and Global Health, University of California San Diego, San Diego, California, USA., Heaton RK; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Ellis RJ; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA., Letendre SL; HIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California San Diego, San Diego, California, USA.
المصدر: Journal of medical virology [J Med Virol] 2024 Mar; Vol. 96 (3), pp. e29550.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: HIV-1*/genetics , HIV Infections*, Humans ; RNA, Viral ; Iron ; Serum Globulins/metabolism ; Serum Globulins/therapeutic use ; Viral Load
مستخلص: Interindividual variation of human immunodeficiency virus (HIV) RNA setpoint in cerebrospinal fluid (CSF) and its determinants are poorly understood, but relevant for HIV neuropathology, brain reservoirs, viral escape, and reseeding after antiretroviral interruptions. Longitudinal multicentric study on demographic, clinical, and laboratory correlates of CSF HIV RNA in 2000 follow-up visits from 597 people with HIV (PWH) off antiretroviral therapy (ART) and with plasma HIV RNA > the lower limit of quantification (LLQ). Factors associated with CSF control (CSFC; CSF HIV RNA < LLQ while plasma HIV RNA > LLQ) and with CSF/plasma discordance (CSF > plasma HIV RNA > LLQ) were also assessed through mixed-effects models. Posthoc and sensitivity analyses were performed for persistent CSFC and ART-naïve participants, respectively. Over a median follow-up of 2.1 years, CSF HIV RNA was associated with CD4+ and CD8+ T cells, CSF leukocytes, blood-brain barrier (BBB) integrity, biomarkers of iron and lipid metabolism, serum globulins, past exposure to lamivudine, and plasma HIV RNA (model p < 0.0001). CSFC (persistent in 7.7% over 3 years) and CSF/plasma discordance (persistent in <0.01% over 1 year) were variably associated with the same parameters (model p < 0.001). Sensitivity analyses confirmed most of the previous associations in participants never exposed to ART. Persistent CSFC was associated with higher CD4 + T-cell count nadir (p < 0.001), lower serum globulins (p = 0.003), and lower CSF leukocytes (p < 0.001). Without ART, one in 13 PWH had persistently undetectable CSF HIV RNA, while persistent CSF/plasma discordance was extremely rare over years. Immune responses, inflammation, BBB permeability, and iron and lipid metabolism were all associated with HIV replication in CSF.
(© 2024 Wiley Periodicals LLC.)
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معلومات مُعتمدة: P50 DA026306 United States DA NIDA NIH HHS; R25 MH081482 United States MH NIMH NIH HHS; R01 MH07345 United States MH NIMH NIH HHS; P30 MH062512 United States MH NIMH NIH HHS; P30 MH62512 United States MH NIMH NIH HHS; P50 DA26306 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: CSF control; CSF/plasma discordance; HIV viral load; antiretroviral naïve; blood–brain barrier; central nervous system
المشرفين على المادة: 0 (RNA, Viral)
E1UOL152H7 (Iron)
0 (Serum Globulins)
تواريخ الأحداث: Date Created: 20240321 Date Completed: 20240322 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC11139255
DOI: 10.1002/jmv.29550
PMID: 38511593
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.29550